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dc.creatorKim, TW
dc.creatorPark, SS
dc.creatorPark, JY
dc.creatorPark, HS
dc.date.accessioned2020-12-15T20:55:47Z
dc.date.available2020-12-15T20:55:47Z
dc.date.issued2020-05-01
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4465
dc.identifier.other32384696 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4483
dc.description.abstract© 2020, MDPI AG. All rights reserved. Alzheimer’s disease is the most common neurodegenerative brain disease causing dementia. It is characterized by slow onset and gradual worsening of memory and other cognitive functions. Recently, parabiosis and infusion of plasma from young mice have been proposed to have positive effects in aging and Alzheimer’s disease. Therefore, this study examined whether infusion of plasma from exercised mice improved cognitive functions related to the hippocampus in a 3xTg-Alzheimer’s disease (AD) model. We collected plasma from young mice that had exercised for 3 months and injected 100 µL of plasma into the tail vein of 12-month-old 3xTg-AD mice 10 times at 3-day intervals. We then analyzed spatial learning and memory, long-term memory, hippocampal GSK3β/tau proteins, synaptic proteins, mitochondrial function, apoptosis, and neurogenesis. In the hippocampus of 3xTg-AD mice, infusion of plasma from exercised mice improved neuroplasticity and mitochondrial function and suppressed apoptosis, ultimately improving cognitive function. However, there was no improvement in tau hyperphosphorylation. This study showed that plasma from exercised mice could have a protective effect on cognitive dysfunction and neural circuits associated with AD via a tau-independent mechanism involving elevated brain-derived neurotrophic factor due to exercise.
dc.format.extent3291-3291
dc.language.isoen
dc.relation.haspartInternational Journal of Molecular Sciences
dc.relation.isreferencedbyMDPI AG
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectcognitive function
dc.subjectexercise
dc.subjecthippocampus
dc.subjectmitochondria
dc.subjectneuroplasticity
dc.subjectyoung plasma
dc.titleInfusion of plasma from exercised mice ameliorates cognitive dysfunction by increasing hippocampal neuroplasticity and mitochondrial functions in 3xtg-ad mice
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.3390/ijms21093291
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2020-12-15T20:55:42Z
refterms.dateFOA2020-12-15T20:55:47Z


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