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dc.creatorLeitner, T
dc.creatorKumar, S
dc.date.accessioned2020-12-15T20:25:21Z
dc.date.available2020-12-15T20:25:21Z
dc.date.issued2020-09-01
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4450
dc.identifier.other32893295 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4468
dc.description.abstract© The Author(s) 2020. Identifying the origin of SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, may help us to avoid future epidemics of coronavirus and other zoonoses. Several theories about the zoonotic origin of SARS-CoV-2 have recently been proposed. Although Betacoronavirus found in Rhinolophus bats from China have been broadly implicated, their genetic dissimilarity to SARS-CoV-2 is so high that they are highly unlikely to be its direct ancestors. Thus, an intermediary host is suspected to link bat to human coronaviruses. Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastrointestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. Therefore, reduced genomic CpG alone is not a highly predictive biomarker, suggesting a need for additional biomarkers to reveal intermediate hosts or tissues. The hunt for the zoonotic origin of SARS-CoV-2 continues.
dc.format.extent2463-2464
dc.language.isoen
dc.relation.haspartMolecular Biology and Evolution
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rights.uriAll Rights Reserved
dc.subjectorigins
dc.subjectevolution
dc.subjectpandemic
dc.subjectSARS-CoV-2
dc.titleWhere Did SARS-CoV-2 Come From?
dc.typeArticle
dc.type.genrePre-print
dc.relation.doi10.1093/molbev/msaa162
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidKumar, Sudhir|0000-0002-9918-8212
dc.date.updated2020-12-15T20:25:18Z
refterms.dateFOA2020-12-15T20:25:21Z


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