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dc.creatorWickens, MM
dc.creatorBangasser, DA
dc.creatorBriand, LA
dc.date.accessioned2020-12-14T21:16:21Z
dc.date.available2020-12-14T21:16:21Z
dc.date.issued2018-06-05
dc.identifier.issn1662-5099
dc.identifier.issn1662-5099
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4423
dc.identifier.otherGI2IZ (isidoc)
dc.identifier.other29922129 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4441
dc.description.abstract© 2018 Wickens, Bangasser and Briand. Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated in several psychiatric diseases. Many of these psychiatric diseases display epidemiological sex differences, with either males or females exhibiting different symptoms or disease prevalence. However, little work has considered the interaction of disrupted glutamatergic transmission and sex on disease states. This review describes the clinical and preclinical evidence for these sex differences with a focus on two conditions that are more prevalent in women: Alzheimer’s disease and major depressive disorder, and three conditions that are more prevalent in men: schizophrenia, autism spectrum disorder, and attention deficit hyperactivity disorder. These studies reveal sex differences at multiple levels in the glutamate system including metabolic markers, receptor levels, genetic interactions, and therapeutic responses to glutamatergic drugs. Our survey of the current literature revealed a considerable need for more evaluations of sex differences in future studies examining the role of the glutamate system in psychiatric disease. Gaining a more thorough understanding of how sex differences in the glutamate system contribute to psychiatric disease could provide novel avenues for the development of sex-specific pharmacotherapies.
dc.format.extent197-
dc.language.isoeng
dc.relation.haspartFrontiers in Molecular Neuroscience
dc.relation.isreferencedbyFrontiers Media SA
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectsex differences
dc.subjectglutamate
dc.subjectADHD
dc.subjectAlzheimer'sdisease
dc.subjectschizophrenia
dc.subjectautism spectrum disorders (ASD)
dc.subjectdepression
dc.titleSex differences in psychiatric disease: A focus on the glutamate system
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.3389/fnmol.2018.00197
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2020-12-14T21:16:19Z
refterms.dateFOA2020-12-14T21:16:22Z


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