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dc.creatorKearney, SE
dc.creatorZahoránszky-Kohalmi, G
dc.creatorBrimacombe, KR
dc.creatorHenderson, MJ
dc.creatorLynch, C
dc.creatorZhao, T
dc.creatorWan, KK
dc.creatorItkin, Z
dc.creatorDillon, C
dc.creatorShen, M
dc.creatorCheff, DM
dc.creatorLee, TD
dc.creatorBougie, D
dc.creatorCheng, K
dc.creatorCoussens, NP
dc.creatorDorjsuren, D
dc.creatorEastman, RT
dc.creatorHuang, R
dc.creatorIannotti, MJ
dc.creatorKaravadhi, S
dc.creatorKlumpp-Thomas, C
dc.creatorRoth, JS
dc.creatorSakamuru, S
dc.creatorSun, W
dc.creatorTitus, SA
dc.creatorYasgar, A
dc.creatorZhang, YQ
dc.creatorZhao, J
dc.creatorAndrade, RB
dc.creatorBrown, MK
dc.creatorBurns, NZ
dc.creatorCha, JK
dc.creatorMevers, EE
dc.creatorClardy, J
dc.creatorClement, JA
dc.creatorCrooks, PA
dc.creatorCuny, GD
dc.creatorGanor, J
dc.creatorMoreno, J
dc.creatorMorrill, LA
dc.creatorPicazo, E
dc.creatorSusick, RB
dc.creatorGarg, NK
dc.creatorGoess, BC
dc.creatorGrossman, RB
dc.creatorHughes, CC
dc.creatorJohnston, JN
dc.creatorJoullie, MM
dc.creatorKinghorn, AD
dc.creatorKingston, DGI
dc.creatorKrische, MJ
dc.creatorKwon, O
dc.creatorMaimone, TJ
dc.creatorMajumdar, S
dc.creatorMaloney, KN
dc.creatorMohamed, E
dc.creatorMurphy, BT
dc.creatorNagorny, P
dc.creatorOlson, DE
dc.creatorOverman, LE
dc.creatorBrown, LE
dc.creatorSnyder, JK
dc.creatorPorco, JA
dc.creatorRivas, F
dc.creatorRoss, SA
dc.creatorSarpong, R
dc.creatorSharma, I
dc.creatorShaw, JT
dc.creatorXu, Z
dc.creatorShen, B
dc.creatorShi, W
dc.creatorStephenson, CRJ
dc.creatorVerano, AL
dc.creatorTan, DS
dc.creatorTang, Y
dc.creatorTaylor, RE
dc.creatorThomson, RJ
dc.creatorVosburg, DA
dc.creatorWu, J
dc.creatorWuest, WM
dc.creatorZakarian, A
dc.creatorZhang, Y
dc.creatorRen, T
dc.creatorZuo, Z
dc.creatorInglese, J
dc.creatorMichael, S
dc.creatorSimeonov, A
dc.creatorZheng, W
dc.creatorShinn, P
dc.creatorJadhav, A
dc.creatorBoxer, MB
dc.creatorHall, MD
dc.creatorXia, M
dc.creatorGuha, R
dc.creatorRohde, JM
dc.date.accessioned2020-12-11T21:04:46Z
dc.date.available2020-12-11T21:04:46Z
dc.date.issued2018-12-26
dc.identifier.issn2374-7943
dc.identifier.issn2374-7951
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4348
dc.identifier.otherHF6JH (isidoc)
dc.identifier.other30648156 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4366
dc.description.abstract© 2018 American Chemical Society. Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were analyzed using a variety of quality control metrics, and the resultant assay profiles were explored using statistical methods, such as clustering and compound promiscuity analyses. Individual compounds were then sorted by structural class and activity profiles. Differential behavior based on these classifications, as well as noteworthy activities, are outlined herein. One such highlight is the activity of (-)-2(S)-cathafoline, which was found to stabilize calcium levels in the endoplasmic reticulum. The workflow described here illustrates a pilot effort to broadly survey the biological potential of natural products by utilizing the power of automation and high-throughput screening.
dc.format.extent1727-1741
dc.language.isoen
dc.relation.haspartACS Central Science
dc.relation.isreferencedbyAmerican Chemical Society (ACS)
dc.rightsAll Rights Reserved
dc.subject0305 Organic Chemistry
dc.titleCanvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1021/acscentsci.8b00747
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2020-12-11T21:04:40Z
refterms.dateFOA2020-12-11T21:04:47Z


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