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    Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

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    Name:
    Canvass A Crowd-Sourced, Natur ...
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    Genre
    Journal Article
    Date
    2018-12-26
    Author
    Kearney, SE
    Zahoránszky-Kohalmi, G
    Brimacombe, KR
    Henderson, MJ
    Lynch, C
    Zhao, T
    Wan, KK
    Itkin, Z
    Dillon, C
    Shen, M
    Cheff, DM
    Lee, TD
    Bougie, D
    Cheng, K
    Coussens, NP
    Dorjsuren, D
    Eastman, RT
    Huang, R
    Iannotti, MJ
    Karavadhi, S
    Klumpp-Thomas, C
    Roth, JS
    Sakamuru, S
    Sun, W
    Titus, SA
    Yasgar, A
    Zhang, YQ
    Zhao, J
    Andrade, RB
    Brown, MK
    Burns, NZ
    Cha, JK
    Mevers, EE
    Clardy, J
    Clement, JA
    Crooks, PA
    Cuny, GD
    Ganor, J
    Moreno, J
    Morrill, LA
    Picazo, E
    Susick, RB
    Garg, NK
    Goess, BC
    Grossman, RB
    Hughes, CC
    Johnston, JN
    Joullie, MM
    Kinghorn, AD
    Kingston, DGI
    Krische, MJ
    Kwon, O
    Maimone, TJ
    Majumdar, S
    Maloney, KN
    Mohamed, E
    Murphy, BT
    Nagorny, P
    Olson, DE
    Overman, LE
    Brown, LE
    Snyder, JK
    Porco, JA
    Rivas, F
    Ross, SA
    Sarpong, R
    Sharma, I
    Shaw, JT
    Xu, Z
    Shen, B
    Shi, W
    Stephenson, CRJ
    Verano, AL
    Tan, DS
    Tang, Y
    Taylor, RE
    Thomson, RJ
    Vosburg, DA
    Wu, J
    Wuest, WM
    Zakarian, A
    Zhang, Y
    Ren, T
    Zuo, Z
    Inglese, J
    Michael, S
    Simeonov, A
    Zheng, W
    Shinn, P
    Jadhav, A
    Boxer, MB
    Hall, MD
    Xia, M
    Guha, R
    Rohde, JM
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    Subject
    0305 Organic Chemistry
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/4366
    
    Metadata
    Show full item record
    DOI
    10.1021/acscentsci.8b00747
    Abstract
    © 2018 American Chemical Society. Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were analyzed using a variety of quality control metrics, and the resultant assay profiles were explored using statistical methods, such as clustering and compound promiscuity analyses. Individual compounds were then sorted by structural class and activity profiles. Differential behavior based on these classifications, as well as noteworthy activities, are outlined herein. One such highlight is the activity of (-)-2(S)-cathafoline, which was found to stabilize calcium levels in the endoplasmic reticulum. The workflow described here illustrates a pilot effort to broadly survey the biological potential of natural products by utilizing the power of automation and high-throughput screening.
    Citation to related work
    American Chemical Society (ACS)
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    ACS Central Science
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/4348
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