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dc.creatorYang, Q
dc.creatorLangston, JC
dc.creatorTang, Y
dc.creatorKiani, MF
dc.creatorKilpatrick, LE
dc.date.accessioned2020-12-11T19:55:48Z
dc.date.available2020-12-11T19:55:48Z
dc.date.issued2019-03-02
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4322
dc.identifier.other30917487 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4340
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Protein Kinase C (PKC) is a family composed of phospholipid-dependent serine/threonine kinases that are master regulators of inflammatory signaling. The activity of different PKCs is context-sensitive and these kinases can be positive or negative regulators of signaling pathways. The delta isoform (PKCδ) is a critical regulator of the inflammatory response in cancer, diabetes, ischemic heart disease, and neurodegenerative diseases. Recent studies implicate PKCδ as an important regulator of the inflammatory response in sepsis. PKCδ, unlike other members of the PKC family, is unique in its regulation by tyrosine phosphorylation, activation mechanisms, and multiple subcellular targets. Inhibition of PKCδ may offer a unique therapeutic approach in sepsis by targeting neutrophil-endothelial cell interactions. In this review, we will describe the overall structure and function of PKCs, with a focus on the specific phosphorylation sites of PKCδ that determine its critical role in cell signaling in inflammatory diseases such as sepsis. Current genetic and pharmacological tools, as well as in vivo models, that are used to examine the role of PKCδ in inflammation and sepsis are presented and the current state of emerging tools such as microfluidic assays in these studies is described.
dc.format.extent1498-1498
dc.language.isoen
dc.relation.haspartInternational Journal of Molecular Sciences
dc.relation.isreferencedbyMDPI AG
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPKC
dc.subjectPKC
dc.subjectphosphorylation
dc.subjectmicrofluidics
dc.subjectinflammation
dc.subjectsepsis
dc.titleThe role of tyrosine phosphorylation of protein kinase C delta in infection and inflammation
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.3390/ijms20061498
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidKiani, Mohammad|0000-0003-1533-0179
dc.date.updated2020-12-11T19:55:44Z
refterms.dateFOA2020-12-11T19:55:49Z


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