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dc.creatorSomarelli, JA
dc.creatorGardner, H
dc.creatorCannataro, VL
dc.creatorGunady, EF
dc.creatorBoddy, AM
dc.creatorJohnson, NA
dc.creatorFisk, JN
dc.creatorGaffney, SG
dc.creatorChuang, JH
dc.creatorLi, S
dc.creatorCiccarelli, FD
dc.creatorPanchenko, AR
dc.creatorMegquier, K
dc.creatorKumar, S
dc.creatorDornburg, A
dc.creatorDegregori, J
dc.creatorTownsend, JP
dc.date.accessioned2020-12-11T15:23:50Z
dc.date.available2020-12-11T15:23:50Z
dc.date.issued2020-02-01
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/4281
dc.identifier.other31642480 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4299
dc.description.abstract© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution - and progression - require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.
dc.format.extent320-326
dc.language.isoen
dc.relation.haspartMolecular Biology and Evolution
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsCC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcancer
dc.subjectfitness landscapes
dc.subjectmetastasis
dc.subjectgenomics
dc.subjecttumor phylogenetics
dc.subjectcomparative oncology
dc.titleMolecular Biology and Evolution of Cancer: From Discovery to Action
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1093/molbev/msz242
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidKumar, Sudhir|0000-0002-9918-8212
dc.date.updated2020-12-11T15:23:47Z
refterms.dateFOA2020-12-11T15:23:51Z


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