• Treatment of Drinking Water Using Polymeric Sorbents

      Zhang, Judy (Temple University. Libraries, 2012)
      Ongoing research suggests that the occurrence of pharmaceutical compounds in the environment has become a growing concern. Without a sufficient method of removing pharmaceutical compounds, there has been an increase in levels of antibiotics within our water systems. Research suggests that an accumulating level of antibiotics from human and animal wastes is widespread. Toxicity levels remain largely unknown but a cost effective treatment method must be developed should the pharmaceutical compounds prove to be hazardous. Our goal is to address this problem by using polymer sorbents that can cost effectively remove antibiotics from drinking water. Polymeric adsorbents work by adsorbing hydrophobic and hydrophilic molecules such as antibiotics from water using a high surface area with both continuous pore and polymer phases. Column experiments will be carried out to test the efficiency of the selected polymeric sorbents towards the removal of antibodies present in the water. The size, flow rate, capacity, and regeneration of the column will be designed to be cost effective while removing the maximum amount of potentially hazardous antibiotics. The final result is a small-scale model that can be scaled up for full-size drinking water treatment operations.
    • Two Guns for the Reds: Bessie Burchett, Antisemitism, and Far-Right Philadelphia

      Glasson, Travis (Temple University. Libraries, 2021)
      "Despite its nickname as the “City of Brotherly Love,” Philadelphia saw a disturbing rise of far-right activism during the 1930s. On the frontlines, women saw their place as defenders of children, religion, and the American gender hierarchy against the Red Menace. Philadelphia’s most well-known female, right-wing agitator at this time was Dr. Bessie Burchett. In 1935, armed with two guns under her skirt and a PhD from the University of Pennsylvania, the high school Latin teacher would declare the Philadelphia public school system compromised by Jewish-Communist infiltration, and institute her own local Red Scare. Though the school system was embarrassed by her, and Philadelphia newspapers mocked her incessantly, Bessie Burchett was not alone in her crusade. Burchett’s critics dismissed her politics as fringe, hysterical, and Un-American, but she represented a trend of women’s increasing participation in far right politics. More importantly, Burchett became a cautionary tale for the conservative movement in the United States, particularly after the Second World War. While her obvious Nazi sympathies left few opportunities for vindication following the war, many of her ideas survived in hibernation through mainstream conservatism. This paper follows the life and career of Bessie Burchett through newspaper coverage, the police files of Detective Sergeant Jacob H. Gomborow, and Burchett’s manifesto, Education For Destruction, which outlines her views on communism in the schools, religion, and pride in one’s race."
    • Using Green Infrastructure to Minimize Combined Sewer Overflows

      Danowsky, Joseph (Temple University. Libraries, 2016)
      This project addresses the problems posed by combined sewer systems in high-density urban environments, and aims to minimize combined sewer overflows through an innovative green infrastructure solution. In order to identify the best solution, bioretention basins, green roofs, and permeable pavement were analyzed according to the following criteria: runoff volume reduction, peak flowrate reduction, pollutant treatment rates, greenhouse gas emissions contribution, cost effectiveness, and implementation feasibility. Bioretention basins were found to perform best in almost all criteria considered. Thus, implementation of bioretention basins is the proposed solution. Bioretention has significant potential in cost savings, as well as positive impact on the local economy, and environmental and social benefits.
    • Using Nanoparticle Drug Delivery Mechanisms to Improve Eye Moisture Over Extended Periods of Contact Lens Wear

      Danowsky, Joseph; Temple University. Honors Program (Temple University. Libraries, 2017)
      Millions of people around the world suffer from dry eye symptoms as a result of extended contact lens wear. The objective of this design document is to engineer a solution for chronic dry eyes. The solution must be safe, effective, easy to use, and affordable. The goal of the treatment is to decrease tear film osmolarity by 20 mOsmol/L. Three types of nanotechnologies were considered for this task. The candidate solutions were 1) hydrogel contact lenses infused with lubricant-loaded liposomes, 2) lubricantloaded microemulsions applied as eye drops, and 3) lubricant-loaded niosomes applied as eye drops. All solutions use polyethylene glycol 400 as the primary active ingredient in the lubricant. The three solutions provide a safe treatment option that allows increased bioavailability of drug and increased retention time, as well as controlled release of drug. A combination of candidates 1 and 3 – namely, hydrogel contact lenses infused with lubricant-loaded niosomes – seems to be the best solution because of excellent drug delivery kinetics and minimal safety concerns. The success of this project would encourage further research in niosome-based and contact lens-based drug delivery. It would also allow this company to expand research and development and further specialize in ocular drug delivery.
    • (Z)-Selective Isomerization of Terminal Alkenes using an air-stable Mo(0) Complex

      Dobereiner, Graham; Temple University. Diamond Research Scholars (Temple University. Libraries, 2018)
      Terminal olefin isomerization with transition metal catalysts has emerged in the past decade as a useful means of generating regio- and stereo-selective internal alkenes. In this work, an array of previously characterized and uncharacterized molybdenum(0) phosphine complexes were synthesized and tested by their ability to catalyze olefin isomerization for a variety of reagents. When coupled with co-catalytic acid (TsOH), these catalysts—specifically the cis-Mo(CO)4(PPh3)2 complex—generally produced an excess of the higher energy (Z)-2-alkene isomer from terminal olefin substrates with state-of-the-art selectivity. Importantly, the Mo(0) complexes examined herein are air-stable, simple to produce and isolate, and demonstrate activity with low catalytic loading (0.5%) and under mild conditions (66 °C in THF). This practicality may extend their use to the organic synthesis of fine chemicals without the generation of significant reagent or solvent waste. Furthermore, the activity and unique selectivity observed with these catalysts should encourage further inquiry into other molybdenum-mediated reactions involving olefins.