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dc.creatorVaidya, Anjali
dc.creatorGolbus, Jessica R.
dc.creatorVedage, Natasha A.
dc.creatorMazurek, Jeremy
dc.creatorRaza, Farhan
dc.creatorForfia, Paul R.
dc.date.accessioned2020-10-01T13:12:27Z
dc.date.available2020-10-01T13:12:27Z
dc.date.issued2020-09-17
dc.identifier.citationVaidya A, Golbus JR, Vedage NA, Mazurek J, Raza F, Forfia PR. Virtual echocardiography screening tool to differentiate hemodynamic profiles in pulmonary hypertension. Pulmonary Circulation. July 2020. doi:10.1177/2045894020950225
dc.identifier.issn2045-8940
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/404
dc.identifier.urihttp://hdl.handle.net/20.500.12613/421
dc.description.abstractThis study validated a novel virtual echocardiography screening tool (VEST), which utilized routinely reported echocardiography parameters to predict hemodynamic profiles in pulmonary hypertension (PH) and identify PH due to pulmonary vascular disease (PHPVD). Direct echocardiography imaging review has been shown to predict hemodynamic profiles in PH; however, routine use often overemphasizes Doppler-estimated pulmonary artery systolic pressure (PASPDE), which lacks discriminatory power among hemodynamically varied PH subgroups. In patients with PH of varying subtypes at a tertiary referral center, reported echocardiographic findings needed for VEST, including left atrial size, E:e’ and systolic interventricular septal flattening, were obtained. Receiver operating characteristic analyses assessed the predictive performance of VEST vs. PASPDE in identifying PHPVD, which was later confirmed by right heart catheterization. VEST demonstrated far superior discriminatory power than PASPDE in identifying PHPVD. A positive score was 80.0% sensitive and 75.6% specific for PHPVD with an area under the curve of 0.81. PASPDE exhibited poorer discriminatory power with an area under the curve of 0.56. VEST’s strong discriminatory ability remained unchanged when validated in a second cohort from another tertiary center. We demonstrated that this novel VEST using three routine parameters that can be easily extracted from standard echocardiographic reports can successfully capture PH patients with a high likelihood of PHPVD. During the Covid-19 pandemic, when right heart catheterization and timely access to experts at accredited PH centers may have limited widespread availability, this may assist physicians to rapidly and remotely evaluate PH patients to ensure timely and appropriate care.
dc.format.extent10 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartPulmonary Circulation, Vol. 10, Issue 3
dc.relation.isreferencedbySAGE Publications
dc.rightsAttribution-NonCommercial CC BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEchocardiography
dc.subjectPulmonary hypertension
dc.subjectPulmonary arterial hypertension
dc.subjectCovid-19
dc.subjectInformation technology/ informatics/ telemedicine
dc.titleVirtual echocardiography screening tool to differentiate hemodynamic profiles in pulmonary hypertension
dc.typeText
dc.type.genreJournal article
dc.description.departmentMedicine
dc.relation.doihttps://doi.org/10.1177/2045894020950225
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorVaidya, Anjali
dc.temple.creatorVedage, Natasha A.
dc.temple.creatorForfia, Paul R.
refterms.dateFOA2020-10-01T13:12:27Z


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