HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis
Genre
Journal articleDate
2020-08-25Author
Correale, PierpaoloSaladino, Rita Emilena
Giannarelli, Diana
Sergi, Andrea
Mazzei, Maria Antonietta
Bianco, Giovanna
Giannicola, Rocco
Iuliano, Eleonora
Forte, Iris Maria
Calandruccio, Natale Daniele
Falzea, Antonia Consuelo
Strangio, Alessandra
Nardone, Valerio
Pastina, Pierpaolo
Tini, Paolo
Luce, Amalia
Caraglia, Michele
Caracciolo, Daniele
Mutti, Luciano

Tassone, Pierfrancesco
Pirtoli, Luigi
Giordano, Antonio

Tagliaferri, Pierosandro
Group
Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine (Temple University)Permanent link to this record
http://hdl.handle.net/20.500.12613/4157
Metadata
Show full item recordDOI
http://doi.org/10.3390/cells9091964Abstract
Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1 (PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases, including metastatic non-small-cell lung cancer (mNSCLC), malignant melanoma (MM), head and neck, kidney, and urothelial cancer. Monoclonal antibodies (mAbs) against either PD-1 or PD-L1 are active agents for these patients; however, their use may be complicated by unpredictable immune-related adverse events (irAEs), including immune-related pneumonitis (IRP). We carried out a retrospective multi-institutional statistical analysis to investigate clinical and biological parameters correlated with IRP rate on a cohort of 256 patients who received real-world treatment with PD-1/PD-L1 blocking mAbs. An independent radiological review board detected IRP in 29 patients. We did not find statistical IRP rate correlation with gender, tumor type, specific PD-1 or PD-L1 blocking mAbs, radiation therapy, inflammatory profile, or different irAEs. A higher IRP risk was detected only in mNSCLC patients who received metronomic chemotherapy +/− bevacizumab compared with other treatments prior PD-1/PD-L1 blockade. Moreover, we detected a strong correlation among the IRP rate and germinal expression of HLA-B*35 and DRB1*11, alleles associated to autoimmune diseases. Our findings may have relevant implications in predicting the IRP rate in mNSCLC patients receiving PD-1/PD-L1 blockade and need to be validated on a larger patient series.Citation
Correale P, Saladino RE, Giannarelli D, Sergi A, Mazzei MA, Bianco G, Giannicola R, Iuliano E, Forte IM, Calandruccio ND, Falzea AC, Strangio A, Nardone V, Pastina P, Tini P, Luce A, Caraglia M, Caracciolo D, Mutti L, Tassone P, Pirtoli L, Giordano A, Tagliaferri P. HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis. Cells. 2020; 9(9):1964.Citation to related work
MDPIHas part
CellsADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.eduae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.34944/dspace/4139