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    Etoposide as Salvage Therapy for Cytokine Storm due to COVID-19

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    Patel-PrePrint-2020.pdf
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    Genre
    Pre-print
    Date
    2020-09-12
    Author
    Patel, Maulin
    Dominguez Castillo, Eduardo cc
    Sacher, Daniel cc
    Desai, Parag
    Chandar, Ashwin
    Bromberg, Michael
    Caricchio, Roberto cc
    Criner, Gerard J.
    Group
    COVID-19 Research Group (Temple University)
    Department
    Thoracic Medicine and Surgery
    Hematology and Oncology
    Rheumatology
    Subject
    COVID-19
    Etoposide
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/4153
    
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    DOI
    https://doi.org/10.1016/j.chest.2020.09.077
    Abstract
    Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.
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    Elsevier
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/4135
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