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dc.contributor.advisorSuh, Won H.
dc.creatorYam, Lindsey
dc.date.accessioned2020-11-05T19:50:44Z
dc.date.available2020-11-05T19:50:44Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/20.500.12613/4070
dc.description.abstractIrregular wound healing, experienced by patients suffering from underlying pathology or reoccurring ulcers, is a major concern that often requires outside aid to induce proper healing. A potential therapeutic is KTTKS, a sub-fragment of the type I collagen pro-peptide which can facilitate extracellular matrix secretion from fibroblasts. Prior studies have shown that KTTKS can upregulate TGF-β and collagen deposition, which can facilitate faster cell migration into the wound bed and decrease overall wound closure time. However, the water-soluble nature of KTTKS decreases its bioactivity at the wound site. Attachment of a vinyl functional group to KTTKS allows conjugation into the backbone of a radically polymerizable hydrogel skin mimic. This formulation is hypothesized to increase the efficiency of KTTKS compared to existing configurations which contain non-immobilized peptides.
dc.format.extent42 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBioengineering
dc.titleThe Preparation and Characterization of the Collagen Signal Peptide Lys-Thr-Thr-Lys-Ser and Its Derivatives
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberLelkes, Peter I.
dc.contributor.committeememberHar-el, Yah-el
dc.description.departmentBioengineering
dc.relation.doihttp://dx.doi.org/10.34944/dspace/4052
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreeM.S.
refterms.dateFOA2020-11-05T19:50:44Z


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