EVALUATION OF THE COMBINATION OF PROSTANOIDS AND FEMALE SEX HORMONES AS INFLAMMATION BIOMARKERS AND THEIR IMPLICATION ON HYPERTENSION

Abstract

Hypertension is a chronic medical condition, and a primary contributor to severe cardiovascular disease. It can increase mortality risk. Studies have found that a low-grade inflammation is involved in the development of hypertension. In addition, men have been found to have a higher risk of hypertension than age-matched women, while women have an increased risk of hypertension after menopause. Female sex hormones are considered to play a protective role in the development and progression of hypertension. Prostanoids are inflammatory mediators, and have important physiological roles on promoting or suppressing inflammation. Studying the combined roles of these two biochemical families in disease development will be helpful to understand the balance between a self-protective effect and inflammatory response in hypertension, and find effective biomarkers to predict the progression of hypertension. In my study, a reversed phase high performance liquid chromatography is used to develop the