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dc.contributor.advisorSoprano, Kenneth J.
dc.creatorZhao, Jianhua
dc.date.accessioned2020-11-05T16:15:56Z
dc.date.available2020-11-05T16:15:56Z
dc.date.issued2009
dc.identifier.other864884506
dc.identifier.urihttp://hdl.handle.net/20.500.12613/3934
dc.description.abstractThe biological activities of retinoic acid (RA) and its synthetic analogues are mediated through nuclear receptors, termed retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The transcriptional activity of RAR on target gene expression is achieved by its AF-1 domain and AF-2 domain. The function of AF-2 is known to be mediated by a number of coregulatory proteins. However the mechanism of AF-1 function is not well studied. We have hypothesized that the AF-1 function of RAR is regulated by specific interacting proteins. HACE1 was identified as an AF-1 domain interacting protein in a yeast two-hybrid screen. HACE1 interacts with RAR&beta<sub>3
dc.format.extent173 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiology, Molecular
dc.subjectHace1
dc.subjectRar
dc.subjectRepressor
dc.titleHACE1, a Novel Repressor of RAR Transcriptional Activity
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberSoprano, Dianne R.
dc.contributor.committeememberTsygankov, Alexander
dc.contributor.committeememberLong, Walter K.
dc.description.departmentMicrobiology and Immunology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/3916
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-11-05T16:15:56Z


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