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dc.contributor.advisorWang, Hong, 1956 September 19-
dc.creatorZhang, Lixiao
dc.date.accessioned2020-11-05T16:15:56Z
dc.date.available2020-11-05T16:15:56Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12613/3929
dc.description.abstractBackground: Epidemiology, clinical trials and meta-analysis studies have established that Hyperhomocysteinemia (HHcy) is an independent risk factor for stroke. However, the exact molecular mechanism underlying the HHcy-induced risk of stroke is unclear. Our study aims to investigate the role of HHcy in stroke. Methods and results: We established a mice mode of focal ischemic stroke, termed transient Middle Cerebral Artery Occlusion (tMCAO) and conducted surgery on a mice model of HHcy (plasma homocysteine level ~150μM), in which a Zn2+ inducible human cystathionine β-synthase (CBS) transgene was introduced to circumvent the neonatal lethality of the CBS gene deficiency (Tg-hCBS Cbs-/- mice). Fourteen-week-old male mice were used in the experiment. A student’s t-test was used for the evaluation of the statistical significance between the two groups. For the comparison across multiple groups, one-way ANOVA was used. We found that HHcy 1) increased the infarction volume from 42.3 ± 4.9 mm
dc.format.extent168 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHealth Sciences
dc.subjectPharmacology
dc.subjectBiology
dc.subjectHomocysteine
dc.subjectIcam1
dc.subjectLy6c
dc.subjectMonocyte
dc.subjectNeutrophil
dc.subjectStroke
dc.titleHYPERHOMOCYSTEINEMIA ACCELERATES STROKE-INDUCED BRAIN INJURY VIA PROMOTING ENDOTHELIAL ACTIVATION AND INFLAMMATORY CELL INFILTRATION: THE ROLE OF ICAM1-MEDIATED NEUTROPHIL AND MONOCYTE INFILTRATION
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberYang, Xiao-Feng
dc.contributor.committeememberAshby, Barrie
dc.contributor.committeememberPersidsky, Yuri
dc.contributor.committeememberEguchi, Satoru
dc.contributor.committeememberYu, Jun
dc.contributor.committeememberZhow, Bin
dc.description.departmentPharmacology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/3911
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-11-05T16:15:56Z


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