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dc.creatorBreit, Markus
dc.creatorKessler, Marcus
dc.creatorStepniewski, Martin
dc.creatorVlachos, Andreas
dc.creatorQueisser, Gillian
dc.date.accessioned2020-04-20T15:58:11Z
dc.date.available2020-04-20T15:58:11Z
dc.date.issued2018-10-23
dc.identifier.citationSpine-to-Dendrite Calcium Modeling Discloses Relevance for Precise Positioning of Ryanodine Receptor-Containing Spine Endoplasmic Reticulum. Scientific Reports 8, Article number: 15624(2018): 1-17. https://doi.org/10.1038/s41598-018-33343-9
dc.identifier.issn2045-2322
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/25
dc.identifier.urihttp://hdl.handle.net/20.500.12613/38
dc.description.abstractThe endoplasmic reticulum (ER) forms a complex endomembrane network that reaches into the cellular compartments of a neuron, including dendritic spines. Recent work discloses that the spine ER is a dynamic structure that enters and leaves spines. While evidence exists that ER Ca2+ release is involved in synaptic plasticity, the role of spine ER morphology remains unknown. Combining a new 3D spine generator with 3D Ca2+ modeling, we addressed the relevance of ER positioning on spine-to-dendrite Ca2+ signaling. Our simulations, which account for Ca2+ exchange on the plasma membrane and ER, show that spine ER needs to be present in distinct morphological conformations in order to overcome a barrier between the spine and dendritic shaft. We demonstrate that RyR-carrying spine ER promotes spine-to-dendrite Ca2+ signals in a position-dependent manner. Our simulations indicate that RyR-carrying ER can initiate time-delayed Ca2+ reverberation, depending on the precise position of the spine ER. Upon spine growth, structural reorganization of the ER restores spine-to-dendrite Ca2+communication, while maintaining aspects of Ca2+ homeostasis in the spine head. Our work emphasizes the relevance of precise positioning of RyR-containing spine ER in regulating the strength and timing of spine Ca2+ signaling, which could play an important role in tuning spine-to-dendrite Ca2+ communication and homeostasis.
dc.format.extent17 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund (OAPF)
dc.relation.haspartScientific Reports, Vol. 8, Article number: 15624
dc.relation.isreferencedbySpringer Nature
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiophysical models
dc.subjectCalcium signalling
dc.titleSpine-to-Dendrite Calcium Modeling Discloses Relevance for Precise Positioning of Ryanodine Receptor-Containing Spine Endoplasmic Reticulum
dc.typeText
dc.type.genreReport
dc.description.departmentMathematics
dc.relation.doihttps://doi.org/10.1038/s41598-018-33343-9
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2018-2019 (Philadelphia, Pa.)
dc.temple.creatorQueisser, Gillian
refterms.dateFOA2020-04-20T15:58:11Z


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