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    CHARACTERIZING THE PHARMACOLOGICAL PROFILE OF MEPHEDRONE AND DETERMINING THE ABUSE LIABILITY MECHANISMS

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    TETDEDXSaber-temple-0225E-12752.pdf
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    Genre
    Thesis/Dissertation
    Date
    2017
    Author
    Saber, Iman A.
    Advisor
    Walker, Ellen A.
    Committee member
    Childers, Wayne E.
    Unterwald, Ellen M.
    Ward, Sara Jane
    Rawls, Scott M.
    Canney, Daniel J.
    Department
    Pharmaceutical Sciences
    Subject
    Pharmacology
    Behavioral Sciences
    Neurosciences
    Cathinone
    Dopamine
    Drug Discrimination
    Self-administration
    Serotonin
    Sprague Dawley Rat
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/3507
    
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    DOI
    http://dx.doi.org/10.34944/dspace/3489
    Abstract
    Illicit drug use has been a growing concern over the past few decades. The rise in use of illegal drugs drove the government and law enforcement to aggressively tackle this problem and crackdown on the illicit use of drugs. However, this sparked a further interest in ‘legal highs.’ Before 2011, among the newly popular ‘legal highs’ was ‘Bath Salts.’ Cathinone is a monoamine alkaloid and the active ingredient found in the leaves of the khat plant. The psychoactive form of bath salts may contain a mixture of synthesized cathinones, including, 4-methyl-N-methcathinone (mephedrone), 3,4-methylenedioxy-N- methylcathinone (methylone) and methylenedioxypyrovalerone (MDPV). These three are commonly found in bath salts. One of the major psychoactive ingredients in bath salts is mephedrone. Mephedrone grew in popularity due to its low price, accessibility, and the shortage of MDMA, thus making mephedrone the prime drug to sell as a ‘legal high’ up until 2011 when it became banned in the United S
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