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    The Biology of Dendritic Cells in the Context of Autoimmunity

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    TETDEDXQiu-temple-0225E-13679.pdf
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    Genre
    Thesis/Dissertation
    Date
    2019
    Author
    Qiu, Connie Claire
    Advisor
    Gallucci, Stefania
    Committee member
    Caricchio, Roberto
    Koch, Walter J.
    Tükel, Çagla
    Monestier, Marc
    Gamero, Ana
    Department
    Infectious Disease & Immunity
    Subject
    Immunology
    Autoimmunity
    Curli
    Dendritic Cells
    Plasmacytoid Dendritic Cells
    Stat2
    Systemic Lupus Erythematosus
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/3433
    
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    DOI
    http://dx.doi.org/10.34944/dspace/3415
    Abstract
    Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects at least five million people worldwide. An increased expression of type I interferon (IFN) regulated genes is a hallmark of SLE, but the precise etiology of SLE initiation and flares is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been suspected, with murine pDC depletion models successfully delaying the progression of murine lupus-like disease. However, the mechanism behind how exactly how pDCs contribute to lupus autoimmunity is unknown, contributing to the current dearth lack of disease modifying treatments; current treatments only succeed in suppressing symptoms, and do not halt disease progression. In this study, we take a multifactorial approach to understanding the biology of pDCs in the context of lupus autoimmunity. Although the exact etiology of lupus is unknown, infections are an important environmental trigger for
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