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    Single-Molecule Study of β-Catenin Translocation and the Role of Custos in its Regulation

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    Schnell_temple_0225E_14201.pdf
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    Genre
    Thesis/Dissertation
    Date
    2020
    Author
    Schnell, Steven cc
    Advisor
    Habas, Raymond
    Committee member
    Waring, Richard B.
    Yang, Weidong, Dr.
    Klein, Peter S.
    Department
    Biology
    Subject
    Developmental Biology
    Cellular Biology
    Molecular Biology
    Beta-catenin
    Custos
    Microscopy
    Super-resolution
    Wnt Signaling
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/324
    
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    DOI
    http://dx.doi.org/10.34944/dspace/308
    Abstract
    The nuclear pore complex is closely involved in the regulation and control of many cellular processes, including the movement of molecules into and out of the nucleus along with the regulation of gene transcription. It is therefore a major barrier for controlling the passage of signaling molecules into and out of the nucleus. β-catenin is one such signaling molecule, and a primary signaling molecule of the Wnt signaling pathway. How the passage of β-catenin into and out of the nucleus is controlled remains poorly defined. This signaling pathway governs major developmental processes, including cell fate determination, proliferation, motility and primary axis and head formation during development. In this study, we use super-resolution microscopy to show that β-catenin import requires Custos as a docking protein. Custos and β-catenin form a complex in the cytoplasm and move together through the NPC into the nucleus, where they dissociate in the nucleus. Further, we provide evidence that import of β-catenin into the nucleus is a regulatory event at the NPC and define regions within the β-catenin protein required for this regulation.
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