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    A PREFORMULATION DEVELOPMENT STUDY FOR THE TRANSUNGUAL DELIVERY OF THE ANTIFUNGAL DRUG ECONAZOLE NITRATE

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    Genre
    Thesis/Dissertation
    Date
    2013
    Author
    Li, Cong
    Advisor
    Lebo, David
    Committee member
    Korzekwa, Kenneth
    Fassihi, Reza
    Canney, Daniel J.
    Department
    Pharmaceutical Sciences
    Subject
    Pharmaceutical Sciences
    Drug Delivery
    Enconazole Nitrate
    Penetration Enhancer
    Transangual
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/3198
    
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    DOI
    http://dx.doi.org/10.34944/dspace/3180
    Abstract
    Onychomycosis is the most common disease of nails and constitutes about a half of all nail abnormalities. The thickness of the nails become the major challenge in developing a topical formulation for treatment on OM. In this study, penetration enhancers are used to enhance the solubility and permeability of the drug enconazole nitrate into the nail and the skin. It turns out of all the penetration enhancers, thiourea is the best choice because it can improve the solubility and nail penetration of econazole nitrate at the same time.
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