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dc.contributor.advisorKunapuli, Satya P.
dc.creatorInamdar, Vaishali Vijay
dc.date.accessioned2020-11-04T16:09:41Z
dc.date.available2020-11-04T16:09:41Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12613/3050
dc.description.abstractPlatelets are small anucleate cells in blood that are derived from megakaryocytes and their primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen gets exposed to which platelets bind and aggregate eventually forming a platelet plug. There are several receptors on platelet surface that can be divided into two broad categories; the immune-receptor tyrosine-based activation motif (ITAM) and the G protein-coupled receptors (GPCRs). The role of several protein tyrosine kinases (PTKs) downstream of ITAM and GPCRs has been extensively studied. However, the role of protein tyrosine phosphatases (PTPs) have been under-investigated in platelets. PTPs are important for dephosphorylating and activating or inactivating the protein. Proteomics studies show presence of 10 receptor like and 10 cytoplasmic phosphatases in platelets. To date, only five non-transmembrane PTPs (NTPTPs), PTP-1B, Shp1, Shp2, LMW-PTP, MEG2-PTP and a one receptor- like PTP (RPTP), CD148,
dc.format.extent128 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectPhysiology
dc.titleFUNCTIONAL PROTEIN TYROSINE PHOSPHATASES IN PLATELETS
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberScalia, Rosario
dc.contributor.committeememberKilpatrick, Laurie
dc.contributor.committeememberChen, Xiongwen
dc.contributor.committeememberNaik, Ulhas P.
dc.description.departmentBiomedical Sciences
dc.relation.doihttp://dx.doi.org/10.34944/dspace/3032
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-11-04T16:09:41Z


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