• Login
    View Item 
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of TUScholarShareCommunitiesDateAuthorsTitlesSubjectsGenresThis CollectionDateAuthorsTitlesSubjectsGenres

    My Account

    LoginRegister

    Help

    AboutPeoplePoliciesHelp for DepositorsData DepositFAQs

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Storm, Stress, and Nicotine: Examining the interactive effects of adolescent stress and adolescent nicotine on the development of long-term learning deficits

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    TETDEDXHolliday_temple_0225E_1 ...
    Size:
    1.285Mb
    Format:
    PDF
    Download
    Genre
    Thesis/Dissertation
    Date
    2015
    Author
    Holliday, Erica
    Advisor
    Gould, Thomas John, 1966-
    Committee member
    Bangasser, Debra A.
    Chein, Jason M.
    Parikh, Vinay
    Briand, Lisa A.
    Drabick, Deborah A.
    Department
    Psychology
    Subject
    Behavioral Sciences
    Neurosciences
    Psychology
    Adolescent
    Contextual Fear
    Hippocampus
    Nicotine
    Stress
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/3017
    
    Metadata
    Show full item record
    DOI
    http://dx.doi.org/10.34944/dspace/2999
    Abstract
    In order to continue the decline of smoking prevalence, it is imperative to understand the factors that contribute to the development of nicotine and tobacco addiction, such as adolescent initiation of nicotine use, stress, and the interaction of adolescent stress and adolescent nicotine. Both clinical and preclinical literature indicates that adolescent, but not adult, nicotine administration leads to long-lasting impairments in learning and memory and affect. Specifically, chronic nicotine treatment beginning in early adolescence or late adolescence resulted in adult deficits in contextual fear learning. However, the current study demonstrated that these adult learning deficits did not occur solely from nicotine administration. Rather, an interaction between adolescent nicotine and adolescent stress resulted in adult learning deficits in contextual fear. Additionally, it was found that dietary choline supplementation that began immediately following cessation of adolescent nicotine treatment and continued through a protracted abstinence period lasting thirty days reversed adult deficits in contextual fear. Finally, the current study found that adolescent nicotine exposure beginning at either early adolescence or late adolescence increased depressive-like behaviors, but not anxiety-like behaviors, following a protracted abstinence period. In contrast, chronic nicotine treatment in adult increased anxiety-like behaviors measured by the elevated plus-maze following a protracted abstinence period. The work encompassed in this dissertation suggests that the interactions between adolescent stress and adolescent nicotine increases the risk for developing cognitive and affective impairments, which may promote continued use of nicotine in adulthood.
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    Collections
    Theses and Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Temple University Libraries | 1900 N. 13th Street | Philadelphia, PA 19122
    (215) 204-8212 | scholarshare@temple.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.