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dc.contributor.advisorSuh, Won H.
dc.creatorHoff, Richard
dc.date.accessioned2020-11-04T15:20:05Z
dc.date.available2020-11-04T15:20:05Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/20.500.12613/3013
dc.description.abstractMultifunctional nanomaterials can be engineered to aid in the diagnosis of diseases, enable efficient drug delivery, monitor treatment progress over time, and evaluate treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials’ properties and their customization for specific medical applications has therefore been a significant area of interest within the scientific community. Iron oxide nanoparticles, specifically those based on iron (II, III) oxide (magnetite, Fe3O4), have been prominently investigated for biomedical, theranostic applications due to their documented superparamagnetism, high biocompatibility, and other unique physicochemical properties. The aim of this thesis is to establish a viable set of methods for preparing magnetite (iron oxide) nanoparticles through hydrothermal synthesis and modifying their surfaces with organic functional groups in order to both modulate surface chemistry and facilitate the attachment of molecules such as peptides via covalent bond formations. Modifying their surfaces with biomolecules such as peptides can further increase their uptake into cells, which is a necessary step in the mechanisms of their desired biomedical applications. The methods of nanoparticle synthesis, surface functionalization, and characterization involving electron microscopy (e.g., SEM, TEM), zeta potential measurements, size analysis (i.e., DLS), and FT-IR spectroscopy will be presented.
dc.format.extent65 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBioengineering
dc.subjectEngineering, Biomedical
dc.subjectMaterials Science
dc.subjectBiocompatibility
dc.subjectCharacterization
dc.subjectHydrothermal Synthesis
dc.subjectMagnetite
dc.subjectNanoparticles
dc.subjectSurface Functionalization
dc.titleIron Oxide Nanoparticle Surface Modification: Synthesis and Characterization
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberLelkes, Peter I.
dc.contributor.committeememberHar-el, Yah-el
dc.description.departmentBioengineering
dc.relation.doihttp://dx.doi.org/10.34944/dspace/2995
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreeM.S.
refterms.dateFOA2020-11-04T15:20:05Z


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