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Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

dc.creatorPollak, Nina M.
dc.creatorHoffman, Matthew
dc.creatorGoldberg, Ira J.
dc.creatorDrosatos, Konstantinos
dc.date.accessioned2020-04-20T15:29:42Z
dc.date.available2020-04-20T15:29:42Z
dc.date.issued2018-02-01
dc.identifier.citationNina M. Pollak, Matthew Hoffman, Ira J. Goldberg, Konstantinos Drosatos (2019) Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways. JACC: Basic to Translational Science, 3(1): 132-156, https://doi.org/10.1016/j.jacbts.2017.09.001.
dc.identifier.issn2452-302X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/15
dc.identifier.urihttp://hdl.handle.net/20.500.12613/28
dc.description.abstractKrüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.
dc.format.extent25 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund (OAPF)
dc.relation.haspartJACC: Basic to Translational Science, Vol. 3, Issue 1
dc.relation.isreferencedbyElsevier
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDiabetes
dc.subjectHeart failure
dc.subjectMetabolism
dc.subjectObesity
dc.subjectKrüppel-like factors
dc.titleKrüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
dc.typeText
dc.type.genreJournal article
dc.contributor.groupMetabolic Biology Laboratory, Center for Translational Medicine
dc.description.departmentPharmacology
dc.relation.doihttps://doi.org/10.1016/j.jacbts.2017.09.001
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2017-2018 (Philadelphia, Pa.)
dc.creator.orcid0000-0003-0903-834X
dc.temple.creatorHoffman, Matthew
dc.temple.creatorDrosatos, Konstantinos
refterms.dateFOA2020-04-20T15:29:42Z


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