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    A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex

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    Genre
    Thesis/Dissertation
    Date
    2016
    Author
    Gangolli, Riddhi Ajit
    Advisor
    Yang, Maobin
    Committee member
    Pleshko, Nancy
    Lelkes, Peter I.
    Jefferies, Steven R.
    Department
    Bioengineering
    Subject
    Engineering, Biomedical
    Dentistry
    Biomaterials
    Dental Pulp Stem Cells
    Dentistry
    Guided Tissue Regeneration
    Porous Scaffold
    Regenerative Medicine
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/2896
    
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    DOI
    http://dx.doi.org/10.34944/dspace/2878
    Abstract
    60 % of school children have some form of untreated tooth decay or have suffered trauma to the front teeth which results in pulp damage. If left untreated, these teeth are susceptible to premature fracture/loss under daily stresses. In cases of adolescent tooth loss, teenagers cannot get dental implants until after the growth spurts; their only option is using removable dentures which lowers their quality of life. Conventional endodontic treatment (root canal treatment) is used in cases of pulp necrosis, but cannot be performed in immature permanent teeth due to major differences in tooth anatomy. Currently the American Dental Academy has approved a procedure called Regenerative Endodontic Treatment (RET) for such cases, but the outcomes are still unpredictable and the method is largely unreliable. One issue that we are trying to address in this work is the regeneration of the pulp-dentin complex (PDC), specifically the interface. Endeavors in regenerating either pulp or dentin have been successful individually, but the interface region is the anatomical and physiologic hallmark of the PDC and has not been addressed. We have proposed a biomimetic scaffold to facilitate early stage stratification of these different tissues and allow recapitulation of their interface. Tissue engineering principles and biomaterial processing techniques were used simultaneously to encourage dental pulp stem cells into mineralize selectively only on one side. This effectively allows the scaffold to serve as the interface region between the hard dentin and the soft vascular pulp.
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