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dc.creatorCorreale, Pierpaolo
dc.creatorMutti, Luciano
dc.creatorPentimalli, Francesca
dc.creatorBaglio, Giovanni
dc.creatorSaladino, Rita Emilena
dc.creatorSileri, Pierpaolo
dc.creatorGiordano, Antonio
dc.date.accessioned2020-08-24T17:30:03Z
dc.date.available2020-08-24T17:30:03Z
dc.date.issued2020-07-23
dc.identifier.citationCorreale, P.; Mutti, L.; Pentimalli, F.; Baglio, G.; Saladino, R.E.; Sileri, P.; Giordano, A. HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy. Int. J. Mol. Sci. 2020, 21, 5205.
dc.identifier.issn1422-0067
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/234
dc.identifier.urihttp://hdl.handle.net/20.500.12613/250
dc.description.abstractThe spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, might partly underlie these differences. Through an ecological approach, we analyzed whether a set of HLA alleles (A, B, C), known to be involved in the immune response against infections, correlates with COVID-19 incidence. COVID-19 data were provided by the National Civil Protection Department, whereas HLA allele prevalence was retrieved through the Italian Bone-Marrow Donors Registry. Among all the alleles, HLA-A*25, B*08, B*44, B*15:01, B*51, C*01, and C*03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson’s coefficients between 0.50 and 0.70, p-value < 0.0001), whereas HLA-B*14, B*18, and B*49 showed an inverse log-linear correlation (Pearson’s coefficients between −0.47 and −0.59, p-value < 0.0001). When alleles were examined simultaneously using a multiple regression model to control for confounding factors, HLA-B*44 and C*01 were still positively and independently associated with COVID-19: a growth rate of 16% (95%CI: 0.1–35%) per 1% point increase in B*44 prevalence; and of 19% (95%CI: 1–41%) per 1% point increase in C*01 prevalence. Our epidemiologic analysis, despite the limits of the ecological approach, is strongly suggestive of a permissive role of HLA-C*01 and B*44 towards SARS-CoV-2 infection, which warrants further investigation in case-control studies. This study opens a new potential avenue for the identification of sub-populations at risk, which could provide Health Services with a tool to define more targeted clinical management strategies and priorities in vaccination campaigns.
dc.format.extent12 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartInternational Journal of Molecular Sciences, Vol. 21, Issue 15
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSARS-Cov2
dc.subjectCoronavirus
dc.subjectCOVID-19
dc.subjectHLA class I
dc.subjectViral infection susceptibility
dc.titleHLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
dc.typeText
dc.type.genreJournal article
dc.contributor.groupCenter for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine (Temple University)
dc.relation.doihttps://doi.org/10.3390/ijms21155205
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcid0000-0002-1578-2637
dc.creator.orcid0000-0002-5959-016X
dc.temple.creatorMutti, Luciano
dc.temple.creatorGiordano, Antonio
refterms.dateFOA2020-08-24T17:30:03Z


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