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dc.contributor.advisorKulathinal, Rob J.
dc.creatorStanley, Jr., Craig Edward
dc.date.accessioned2020-11-03T15:33:49Z
dc.date.available2020-11-03T15:33:49Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12613/2455
dc.description.abstractReproduction is among the most dynamic and rapidly evolving genetic systems across sexual taxa. However, the evolutionary mechanisms that drive reproductive traits during the early stages of species divergence are relatively unknown. Using a systems-level, comparative functional genomics approach, I investigate the role of selection, drift, and genomic architecture in promoting the rapid divergence of reproductive systems in Drosophila. I develop a new comparative genomics database, flyDIVaS (Divergence and Selection in Drosophila), an updateable database for identifying patterns and processes involved in species conservation and divergence. I show that tissue-specific genes play a disproportionate role in driving species level divergence and, in particular, that genes specific to male reproductive tissue are among the most rapidly evolving. Using two deeply sequenced populations of Drosophila melanogaster, I reveal that adaptation is widespread among male-specific genes and identify local signatures of selection that have evolved in less than 500 years on sperm motility. In Drosophila mercatorum, a fruit fly capable of facultative parthenogenesis, I find recent signatures of protein changes involved with centrosomal and meiotic functions, and identify early genomic signatures of male degeneration. Among laboratory strains of Drosophila melanogaster, I identify adaptive signatures on neurogenic genes that have recently been domesticated during the last century . Finally, I explore the role of genomic architecture in shaping such reproductive functional systems by developing a novel hypothesis that rapid changes in behavior, such as those found in diverse mating preferences, is a function of the size of the neurogenome. The results presented in this dissertation point toward the importance of selection, drift, and genomic architecture in driving rapid functional change which, together, promote the generation of species diversity via the formation of reproductive barriers in early species divergence.
dc.format.extent236 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiology
dc.subjectGenetics
dc.subjectDrosophila
dc.subjectGenomic Architecture
dc.subjectRapid Evolution
dc.subjectReproductive Systems
dc.titleTHE GENOMIC ARCHITECTURE OF REPRODUCTIVE SYSTEMS IN DROSOPHILA
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberEscalante, Ananias
dc.contributor.committeememberSpigler, Rachel B.
dc.contributor.committeememberRockwell, Christie
dc.description.departmentBiology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/2437
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-11-03T15:33:49Z


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