• Login
    View Item 
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of TUScholarShareCommunitiesDateAuthorsTitlesSubjectsGenresThis CollectionDateAuthorsTitlesSubjectsGenres

    My Account

    LoginRegister

    Help

    AboutPeoplePoliciesHelp for DepositorsData DepositFAQs

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    THE GENOMIC ARCHITECTURE OF REPRODUCTIVE SYSTEMS IN DROSOPHILA

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    StanleyJr_temple_0225E_12968.pdf
    Size:
    11.27Mb
    Format:
    PDF
    Download
    Genre
    Thesis/Dissertation
    Date
    2017
    Author
    Stanley, Jr., Craig Edward
    Advisor
    Kulathinal, Rob J.
    Committee member
    Escalante, Ananias
    Spigler, Rachel B.
    Rockwell, Christie
    Department
    Biology
    Subject
    Biology
    Genetics
    Drosophila
    Genomic Architecture
    Rapid Evolution
    Reproductive Systems
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/2455
    
    Metadata
    Show full item record
    DOI
    http://dx.doi.org/10.34944/dspace/2437
    Abstract
    Reproduction is among the most dynamic and rapidly evolving genetic systems across sexual taxa. However, the evolutionary mechanisms that drive reproductive traits during the early stages of species divergence are relatively unknown. Using a systems-level, comparative functional genomics approach, I investigate the role of selection, drift, and genomic architecture in promoting the rapid divergence of reproductive systems in Drosophila. I develop a new comparative genomics database, flyDIVaS (Divergence and Selection in Drosophila), an updateable database for identifying patterns and processes involved in species conservation and divergence. I show that tissue-specific genes play a disproportionate role in driving species level divergence and, in particular, that genes specific to male reproductive tissue are among the most rapidly evolving. Using two deeply sequenced populations of Drosophila melanogaster, I reveal that adaptation is widespread among male-specific genes and identify local signatures of selection that have evolved in less than 500 years on sperm motility. In Drosophila mercatorum, a fruit fly capable of facultative parthenogenesis, I find recent signatures of protein changes involved with centrosomal and meiotic functions, and identify early genomic signatures of male degeneration. Among laboratory strains of Drosophila melanogaster, I identify adaptive signatures on neurogenic genes that have recently been domesticated during the last century . Finally, I explore the role of genomic architecture in shaping such reproductive functional systems by developing a novel hypothesis that rapid changes in behavior, such as those found in diverse mating preferences, is a function of the size of the neurogenome. The results presented in this dissertation point toward the importance of selection, drift, and genomic architecture in driving rapid functional change which, together, promote the generation of species diversity via the formation of reproductive barriers in early species divergence.
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    Collections
    Theses and Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Temple University Libraries | 1900 N. 13th Street | Philadelphia, PA 19122
    (215) 204-8212 | scholarshare@temple.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.