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    More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

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    Parma-PrePrint-2020-05-24.pdf
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    Genre
    Pre-print
    Date
    2020-05-24
    Author
    Parma, Valentina cc
    Ohla, Kathrin
    Veldhuizen, Maria G.
    Nim, Masha Y.
    Kelly, Christine E.
    Global Consortium for Chemosensory Research
    Reed, Danielle R.
    Hummel, Thomas
    Munger, Steven
    Hayes, John E.
    Department
    Psychology
    Subject
    COVID-19
    Coronavirus infections
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/232
    
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    DOI
    https://doi.org/10.1093/chemse/bjaa041
    Abstract
    Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted to data from single countries. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change+/-100) revealed a mean reduction of smell (-79.7+/- 28.7, mean+/- SD), taste (-69.0+/- 32.6), and chemesthetic (-37.3+/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.
    Citation
    Parma V, Ohla K,Veldhuizen MG, et al. More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses, bjaa041, https://doi.org/10.1093/chemse/bjaa041
    Citation to related work
    This article has been accepted for publication in Chemical Senses Published by Oxford University Press
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    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/216
    Scopus Count
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    COVID-19 Research

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