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    DEVELOPMENT OF NON-DESTRUCTIVE INFRARED FIBER OPTIC METHOD FOR ASSESSMENT OF LIGAMENT AND TENDON COMPOSITION

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    Genre
    Thesis/Dissertation
    Date
    2016
    Author
    Padalkar, Mugdha Vijay
    Advisor
    Pleshko, Nancy
    Committee member
    Barbe, Mary F.
    Ochia, Ruth Shada
    Freeman, T. (Theresa)
    Department
    Bioengineering
    Subject
    Engineering, Biomedical
    Biomechanics
    Biochemistry
    Anterior Cruciate Ligament Injury
    Magnetic Resonance Imaging
    Mechanical Properties
    Partial Least Squares Discriminant Analysis
    Patellat Tendon
    Spectroscopy
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/2081
    
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    DOI
    http://dx.doi.org/10.34944/dspace/2063
    Abstract
    More than 350,000 anterior cruciate ligament (ACL) injuries occur every year in the United States. A torn ACL is typically replaced with an allograft or autograft tendon (patellar, quadriceps or hamstring), with the choice of tissue generally dictated by surgeon preference. Despite the number of ACL reconstructions performed every year, the process of ligamentization, transformation of a tendon graft to a healthy functional ligament, is poorly understood. Previous research studies have relied on mechanical, biochemical and histological studies. However, these methods are destructive. Clinically, magnetic resonance imaging (MRI) is the most common method of graft evaluation, but it lacks adequate resolution and molecular specificity. There is a need for objective methodology to study the ligament repair process that would ideally be non- or minimally invasive. Development of such a method could lead to a better understanding of the effects of therapeutic interventions and rehabilitation protocols in animal models of ligamentization, and ultimately, in clinical studies. Fourier transform infrared (FT-IR) spectroscopy is a technique sensitive to molecular structure and composition in tissues. FT-IR fiber optic probes combined with arthroscopy could prove to be an important tool where minimally invasive tissue assessment is required, such as assessment of graft composition during the ligamentization process. Spectroscopic methods have been used to differentiate normal and diseased connective tissues, but have not been applied to investigate ligamentization, or to investigate differences in tendons and ligaments. In the proposed studies, we hypothesize that infrared spectroscopy can provide molecular information about the compositional differences between tendons and ligaments, which can serve as a foundation to non-destructively monitor the tissue transformation that occurs during ligamentization.
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