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dc.contributor.advisorRamirez, Servio
dc.contributor.advisorPersidsky, Yuri
dc.creatorMerkel, Steven Franklin
dc.date.accessioned2020-10-27T15:27:54Z
dc.date.available2020-10-27T15:27:54Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12613/1910
dc.description.abstractRecent clinical and preclinical reports have identified traumatic brain injury (TBI) as an important risk factor affecting the development of substance use disorders (SUDs). Notably, these studies show that factors like age at the time of injury and TBI severity may increase the risk of substance abuse behavior post-TBI. Furthermore, radiological assessments in clinical TBI populations have observed neuropathology in select brain regions that form key neurocircuits that mediate drug reward and drug-seeking behavior. Therefore, the effects of TBI on the function of these brain structures may influence the risk of substance abuse behavior following brain injury. In order to test the effect of experimental TBI on substance abuse behavior, we utilized two premiere preclinical models: 1) the controlled cortical impact (CCI) model of experimental TBI and 2) a biased, three-phase, cocaine conditioned place preference (CPP) assay. Furthermore, we characterized the effect of experimental TBI on
dc.format.extent163 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectMedicine
dc.subjectPathology
dc.subjectNeurosciences
dc.subjectCocaine
dc.subjectConditioned Place Preference
dc.subjectControlled Cortical Impact
dc.subjectSubstance Abuse
dc.subjectTraumatic Brain Injury
dc.titleEffects of Traumatic Brain Injury on Addiction-Like Behavior and Their Neuropathological Correlates
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberRawls, Scott M.
dc.contributor.committeememberSelzer, Michael E.
dc.contributor.committeememberLangford, Dianne
dc.description.departmentPathology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/1892
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreePh.D.
refterms.dateFOA2020-10-27T15:27:54Z


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