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    Regulation of miR-184 gene expression in early Drosophila development

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    Genre
    Thesis/Dissertation
    Date
    2011
    Author
    Huang, Chen
    Advisor
    Biemar, Frederic
    Committee member
    Palter, Karen
    Department
    Biology
    Subject
    Biology
    Dorsal
    Drosophila
    Gene Expression
    Mir-184
    Twist
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/1475
    
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    DOI
    http://dx.doi.org/10.34944/dspace/1457
    Abstract
    In Drosophila melanogaster, the transcription factor Dorsal initiates dorsal-ventral (DV) patterning in the early embryo by activating or repressing genes, such as the transcription factors Twist and Snail, along the DV axis. Previous studies have shown that the microRNA gene miR-184 in the ventral portion of the embryos (the prospective mesoderm) at the early stages of Drosophila embryogenesis. In order to identify the tissue-specific enhancer that regulates miR-184 expression in the mesoderm, we generated transgenic fly lines and observed the expression of a reporter gene under the control of a potential cis-regulatory module (CRM). Our results show that this CRM is responsible for the regulation of miR-184 and furthermore, it is activated by Twist.
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