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dc.contributor.advisorSciote, James J.
dc.creatorGray, Holly Rose
dc.date.accessioned2020-10-26T19:19:06Z
dc.date.available2020-10-26T19:19:06Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/20.500.12613/1337
dc.description.abstractABSTRACT: Objectives: Masseter muscle fast-fiber composition is reportedly increased on the deviant facial asymmetry side in dentofacial deformities patients. Recently, four distinct asymmetry classes have been identified, based on posterior-anterior cephalometrics in this same population, which may have different functional etiologies. Our aim is to relate muscle fiber type properties with specific asymmetric craniofacial growth in these asymmetry groups. Methods: Diagnostic evaluations, radiographs, and masseter specimens were obtained from orthognathic surgery patients at the University of Lille. Immunohistochemical muscle staining and morphometrics determined the mean areas and percent occupancies of slow-I, fast-II, neonatal, atrial and hybrid fiber types. Eighty-three subjects (twenty nine symmetric, fifty-four asymmetric) had at least unilateral (left or right) fiber type information, while twenty-seven had bilateral (left and right) data. Fiber data were compared between symmetry and asymmetry subjects and between the four asymmetry classes. Significant differences between groups were determined by Fisher’s and ANOVA tests. Results: Type-II mean fiber area (p<0.006) and percent occupancy (p<0.018) were significantly greater on shorter ramal sides in asymmetric compared to symmetric subjects, supporting previous data for facial vertical dimension asymmetry. Neonatal- atrial mean fiber area (p<0.017) and percent occupancy (p<0.027) were decreased in 3 asymmetric groups. No significant difference was found amongst the four asymmetry classes (p<0.05). Conclusions: Imbalanced skeletal proportions are associated with similar imbalances in fiber type properties in left versus right masseter muscle biopsies sampled in the same patient at the time of orthognathic surgery. Specific to our findings, there is an association between increase in neo-atrial and decrease in type II fiber type area and percent occupancy in symmetric patients.
dc.format.extent53 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectDentistry
dc.subjectAsymmetry
dc.subjectFiber Type
dc.subjectMuscle
dc.titleA FIBER TYPE ASSESSMENT OF MASSETER MUSCLES IN FIVE ASYMMETRY CLASSIFICATIONS
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberGodel, Jeffrey H.
dc.contributor.committeememberHorton, Michael J.
dc.contributor.committeememberMoore, John V., III
dc.description.departmentOral Biology
dc.relation.doihttp://dx.doi.org/10.34944/dspace/1319
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreeM.S.
refterms.dateFOA2020-10-26T19:19:06Z


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