A Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy
dc.creator | Yeung, Ho-Man | |
dc.creator | Gupta, Brinda | |
dc.creator | Kamat, Bhishak | |
dc.date.accessioned | 2020-10-23T13:26:10Z | |
dc.date.available | 2020-10-23T13:26:10Z | |
dc.date.issued | 2020-08-02 | |
dc.identifier.citation | Ho-Man Yeung, Brinda Gupta & Bhishak Kamat (2020) A Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy, Journal of Community Hospital Internal Medicine Perspectives, 10:4, 371-376, DOI: 10.1080/20009666.2020.1787809 | |
dc.identifier.issn | 2000-9666 | |
dc.identifier.doi | http://dx.doi.org/10.34944/dspace/1106 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12613/1124 | |
dc.description.abstract | Introduction: Anorectal mucosal melanoma (ARMM) is an uncommon and highly aggressive malignancy. Given its rarity, there is insufficient evidence on the optimal medical management which presents as a clinical challenge to its diagnosis and treatment. Treatment of ARMM typically involves a multimodal approach including surgical resection, chemotherapy, targeted therapy and/or immunotherapy. Case Presentation: Here, we present a case of a 78-year-old female who presented with a four-month history of rectal bleeding and bowel incontinence. Ultimately, colonoscopy revealed a mass at the anal verge, and biopsy of the mass showed malignant cells that stained positive for S100, Melan-A and HMB-45, consistent with the diagnosis of malignant melanoma. Molecular testing revealed no BRAF, KIT or NRAS gene mutations. PD-L1 immunohistochemistry showed tumor proportion score of 1%. She underwent abdominoperineal resection with a plan to initiate immunotherapy with an anti-PD-1 checkpoint inhibitor. This case highlights a rare aggressive malignancy and reviews its treatment option, which are mostly extrapolated from its cutaneous counterpart and some derived from a few case reports. Due to its rarity, there is no consensus guideline for the treatment of ARMM. | |
dc.format.extent | 7 pages | |
dc.language | English | |
dc.language.iso | eng | |
dc.relation.ispartof | Open Access Publishing Fund | |
dc.relation.haspart | Journal of Community Hospital Internal Medicine Perspectives, Vol. 10, 2020, Issue 4 | |
dc.relation.isreferencedby | Taylor & Francis Open Access | |
dc.rights | Attribution-NonCommercial CC BY-NC | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Anorectal melanoma | |
dc.subject | Muscosal melanoma | |
dc.subject | Immunotherapy | |
dc.subject | Gastrointestinal cancer | |
dc.title | A Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy | |
dc.type | Text | |
dc.type.genre | Journal article | |
dc.description.department | Medicine | |
dc.relation.doi | https://doi.org/10.1080/20009666.2020.1787809 | |
dc.ada.note | For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu | |
dc.description.schoolcollege | Lewis Katz School of Medicine | |
dc.description.sponsor | Temple University Libraries Open Access Publishing Fund, 2020-2021 (Philadelphia, Pa.) | |
dc.creator.orcid | 0000-0002-7188-9738 | |
dc.temple.creator | Yeung, Ho-Man | |
dc.temple.creator | Gupta, Brinda | |
dc.temple.creator | Kamat, Bhishak | |
refterms.dateFOA | 2020-10-23T13:26:10Z |