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dc.creatorYeung, Ho-Man
dc.creatorGupta, Brinda
dc.creatorKamat, Bhishak
dc.date.accessioned2020-10-23T13:26:10Z
dc.date.available2020-10-23T13:26:10Z
dc.date.issued2020-08-02
dc.identifier.citationHo-Man Yeung, Brinda Gupta & Bhishak Kamat (2020) A Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy, Journal of Community Hospital Internal Medicine Perspectives, 10:4, 371-376, DOI: 10.1080/20009666.2020.1787809
dc.identifier.issn2000-9666
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/1106
dc.identifier.urihttp://hdl.handle.net/20.500.12613/1124
dc.description.abstractIntroduction: Anorectal mucosal melanoma (ARMM) is an uncommon and highly aggressive malignancy. Given its rarity, there is insufficient evidence on the optimal medical management which presents as a clinical challenge to its diagnosis and treatment. Treatment of ARMM typically involves a multimodal approach including surgical resection, chemotherapy, targeted therapy and/or immunotherapy. Case Presentation: Here, we present a case of a 78-year-old female who presented with a four-month history of rectal bleeding and bowel incontinence. Ultimately, colonoscopy revealed a mass at the anal verge, and biopsy of the mass showed malignant cells that stained positive for S100, Melan-A and HMB-45, consistent with the diagnosis of malignant melanoma. Molecular testing revealed no BRAF, KIT or NRAS gene mutations. PD-L1 immunohistochemistry showed tumor proportion score of 1%. She underwent abdominoperineal resection with a plan to initiate immunotherapy with an anti-PD-1 checkpoint inhibitor. This case highlights a rare aggressive malignancy and reviews its treatment option, which are mostly extrapolated from its cutaneous counterpart and some derived from a few case reports. Due to its rarity, there is no consensus guideline for the treatment of ARMM.
dc.format.extent7 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund
dc.relation.haspartJournal of Community Hospital Internal Medicine Perspectives, Vol. 10, 2020, Issue 4
dc.relation.isreferencedbyTaylor & Francis Open Access
dc.rightsAttribution-NonCommercial CC BY-NC
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAnorectal melanoma
dc.subjectMuscosal melanoma
dc.subjectImmunotherapy
dc.subjectGastrointestinal cancer
dc.titleA Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy
dc.typeText
dc.type.genreJournal article
dc.description.departmentMedicine
dc.relation.doihttps://doi.org/10.1080/20009666.2020.1787809
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2020-2021 (Philadelphia, Pa.)
dc.creator.orcid0000-0002-7188-9738
dc.temple.creatorYeung, Ho-Man
dc.temple.creatorGupta, Brinda
dc.temple.creatorKamat, Bhishak
refterms.dateFOA2020-10-23T13:26:10Z


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