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dc.creatorToribio, Mabel
dc.creatorAwadalla, Magid
dc.creatorDrobni, Zsofia D.
dc.creatorQuinaglia, Thiago
dc.creatorWang, Melissa
dc.creatorDurbin, Claudia G.
dc.creatorAlagpulinsa, David A.
dc.creatorFourman, Lindsay T.
dc.creatorSuero-Abreu, Giselle Alexandra
dc.creatorNelson, Michael D.
dc.creatorStanley, Takara L.
dc.creatorLongenecker, Christopher T.
dc.creatorBurdo, Tricia
dc.creatorNeilan, Tomas G.
dc.creatorZanni, Markella V.
dc.identifier.citationToribio M, Awadalla M, Drobni ZD, Quinaglia T, Wang M, Durbin CG, et al. (2022) Cardiac strain is lower among women with HIV in relation to monocyte activation. PLoS ONE 17(12): e0279913.
dc.description.abstractBackground: Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited. Setting: Massachusetts General Hospital, Boston, Massachusetts. Methods: Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV. Results: WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group, HIV status was an independent predictor of lower GLS. Among WWH (but not among women without HIV), lower GLS related to a higher density of expression of HLA-DR on the surface of CD14+CD16+ monocytes (ρ = -0.45, P = 0.0475). Further, among WWH, inflammatory monocyte activation predicted lower GLS, even after controlling for CD4+ T-cell count and HIV viral load. Conclusions: Additional studies among WWH are needed to examine the role of inflammatory monocyte activation in the pathogenesis of lower GLS and to determine whether targeting this immune pathway may mitigate risks of heart failure and/or adverse heart failure outcomes. Trial registration: Clinical registration: NCT02874703.
dc.format.extent10 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartPLoS ONE, Vol. 17
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.rightsAttribution CC BY
dc.subjectHeart failure
dc.subjectMagnetic resonance imaging
dc.subjectCardiovascular disease risk
dc.subjectMedical risk factors
dc.subjectViral load
dc.titleCardiac strain is lower among women with HIV in relation to monocyte activation
dc.type.genreJournal article
dc.contributor.groupCenter for Neurovirology and Gene Editing (Temple University)
dc.description.departmentMicrobiology, Immunology and Inflammation
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorBurdo, Tricia H.

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