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dc.creatorSumaiya, Krishnamoorthi
dc.creatorPonnusamy, Thiruvelselvan
dc.creatorNatarajaseenivasan, Kalimuthusamy
dc.creatorShanmughapriya, Santhanam
dc.identifier.citationSumaiya, K.; Ponnusamy, T.; Natarajaseenivasan, K.; Shanmughapriya, S. Cardiac Metabolism and MiRNA Interference. Int. J. Mol. Sci. 2023, 24, 50.
dc.description.abstractThe aberrant increase in cardio-metabolic diseases over the past couple of decades has drawn researchers’ attention to explore and unveil the novel mechanisms implicated in cardiometabolic diseases. Recent evidence disclosed that the derangement of cardiac energy substrate metabolism plays a predominant role in the development and progression of chronic cardiometabolic diseases. Hence, in-depth comprehension of the novel molecular mechanisms behind impaired cardiac metabolism-mediated diseases is crucial to expand treatment strategies. The complex and dynamic pathways of cardiac metabolism are systematically controlled by the novel executor, microRNAs (miRNAs). miRNAs regulate target gene expression by either mRNA degradation or translational repression through base pairing between miRNA and the target transcript, precisely at the 3’ seed sequence and conserved heptametrical sequence in the 5’ end, respectively. Multiple miRNAs are involved throughout every cardiac energy substrate metabolism and play a differential role based on the variety of target transcripts. Novel theoretical strategies have even entered the clinical phase for treating cardiometabolic diseases, but experimental evidence remains inadequate. In this review, we identify the potent miRNAs, their direct target transcripts, and discuss the remodeling of cardiac metabolism to cast light on further clinical studies and further the expansion of novel therapeutic strategies. This review is categorized into four sections which encompass (i) a review of the fundamental mechanism of cardiac metabolism, (ii) a divulgence of the regulatory role of specific miRNAs on cardiac metabolic pathways, (iii) an understanding of the association between miRNA and impaired cardiac metabolism, and (iv) summary of available miRNA targeting therapeutic approaches.
dc.format.extent23 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartInternational Journal of Molecular Sciences, Vol. 24, Iss. 1
dc.rightsAttribution CC BY
dc.subjectCardiac metabolism
dc.subjectFatty acid metabolism
dc.subjectGlucose metabolism
dc.subjectATP generation
dc.subjectmiRNA targeting therapy
dc.subjectCardiometabolic disease
dc.titleCardiac Metabolism and MiRNA Interference
dc.type.genreJournal article
dc.description.departmentNeural Sciences
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorNatarajaseenivasan, Kalimuthusamy

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