• A deficit of more than 250,000 public health workers is no way to fight Covid-19

      Taylor Wilson, Robin; Troisi, Catherine L.; Gary-Webb, Tiffany L. (2020-04-05)
    • Administration of intravenous antibiotics in patients with open fractures is dependent on emergency room triaging

      Phillips, Cameron (2018-08-14)
      Recent literature has demonstrated that emergent administration of antibiotics is perhaps more critical than even emergent debridement. Most recent studies recommend patients receive antibiotics no later than 1 hour after injury to prevent infection. The objective of this study is to evaluate the time to antibiotic administration after patients with open fractures arrive to a trauma center depending on triaging team.
    • Coronavirus Disease (Covid-19): What Are We Learning in a Country With High Mortality Rate?

      Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine (Temple University) (2020-05-28)
    • Does interacting with trustworthy people enhance mindfulness? An experience sampling study of mindfulness in everyday situations

      Capraro, Valerio (2019-04-26)
      Mindfulness is known to increase after meditation interventions. But might features of our everyday situations outside of meditation not also influence our mindfulness from moment-to-moment? Drawing from psychological research on interpersonal trust, we suggest that interacting with trustworthy people could influence the expression of mindfulness. And, extending this research on trust, we further suggest that the influence of trustworthy social interactions on mindfulness could proceed through two pathways: a particularized pathway (where specific interactions that are especially high (or low) in trustworthiness have an immediate influence on mindfulness) or a generalized pathway (where the typical level of trustworthiness a person perceives across all their interactions exerts a more stable influence on their mindfulness). To explore these two pathways, study participants (N = 201) repeatedly reported their current levels of mindfulness and their prior interactions with trustworthy leaders and teammates during their everyday situations using an experience sampling protocol ( = 3,605 reports). Results from mixed-effects models provide little support for the particularized pathway: specific interactions with trustworthy leaders and teammates had little immediate association with mindfulness. The generalized pathway, however, was strongly associated with mindfulness—and remained incrementally predictive beyond relevant individual differences and features of situations. In sum, people who typically interact with more trustworthy partners may become more mindful.
    • Examining Adolescence as a Sensitive Period for High-Fat, High-Sugar Diet Exposure: A Systematic Review of the Animal Literature

      Ozanne, Susan (2019-10-25)
      Animal studies suggest that poor nutrition (e.g., high-fat, high-sugar diets) may lead to impairments in cognitive functioning. Accumulating evidence suggests that the deleterious effects of these diets appear more pronounced in animals maintained on this diet early in life, consistent with the notion that the developing brain may be especially vulnerable to environmental insults. The current paper provides the first systematic review of studies comparing the effects of high-fat, high-sugar diet exposure during adolescence and adulthood on memory performance. The majority of studies (7/8) identified here report diet-induced memory problems when diet exposure began in adolescence but not adulthood. These findings lend support to the hypothesis that adolescence is a sensitive period during which palatable diets may contribute to negative neurocognitive effects. The current review explores putative mechanisms involved in diet-induced cognitive dysfunction and highlights promising areas for further research.
    • Incorporating Geographic Information Science and Technology in Response to the COVID-19 Pandemic

      Smith, Charlotte D.; Mennis, Jeremy; 0000-0001-6319-8622 (2020-07-09)
      Incorporating geographic information science and technology (GIS&T) into COVID-19 pandemic surveillance, modeling, and response enhances understanding and control of the disease. Applications of GIS&T include 1) developing spatial data infrastructures for surveillance and data sharing, 2) incorporating mobility data in infectious disease forecasting, 3) using geospatial technologies for digital contact tracing, 4) integrating geographic data in COVID-19 modeling, 5) investigating geographic social vulnerabilities and health disparities, and 6) communicating the status of the disease or status of facilities for return-to-normal operations. Locations and availability of personal protective equipment, ventilators, hospital beds, and other items can be optimized with the use of GIS&T. Challenges include protection of individual privacy and civil liberties and closer collaboration among the fields of geography, medicine, public health, and public policy.
    • Interpersonal Influences on Body Representations in the Infant Brain

      Somogyi, Eszter (2018-12-21)
      Within cognitive neuroscience, there is burgeoning interest in how the body is represented in the adult brain. However, there are large gaps in the understanding of neural body representations from a developmental perspective. Of particular interest are the interconnections between somatosensation and vision, specifically infants’ abilities to register correspondences between their own bodies and the bodies of others. Such registration may play an important role in social learning and in engendering feelings of connectedness with others. In the current study, we further explored the interpersonal aspects of neural body representations by examining whether responses to tactile stimulation in 7-month-old infants are influenced by viewing another’s body. During EEG recording, infants (N= 60) observed a live presentation of an experimenter’s hand or foot being touched. During the presentation of touch to the adult’s hand or foot, the infant received a brief tactile touch to their right hand or right foot. This resulted in four conditions: (i) receive hand stimulation/observe hand stimulation, (ii) receive hand stimulation/observe foot stimulation, (iii) receive foot stimulation/observe hand stimulation, and (iv) receive foot stimulation/observe foot stimulation. Analyses compared responses overlying hand and foot regions when the observed limb matched the stimulated limb (congruent) and did not match (incongruent). In line with prior work, tactile stimulation elicited a somatotopic pattern of results in the somatosensory evoked potential (SEP) and the sensorimotor mu rhythm (6–9 Hz). Cross-modal influences were observed in the beta rhythm (11–13 Hz) response and in the late potential of the SEP response (400–600 ms). Beta desynchronization was greater for congruent compared to incongruent conditions. Additionally, tactile stimulation to the foot elicited larger mean amplitudes for congruent compared to incongruent conditions. The opposite was true for stimulation to the hand. This set of novel findings suggests the importance of considering cross-modal effects in the study of neural body representations in the infant brain. Continued work in this new area of infant neuroscience research can inform how interpersonal aspects of body representations may serve to undergird early social learning.
    • Is Parent–Child Disagreement on Child Anxiety Explained by Differences in Measurement Properties? An Examination of Measurement Invariance Across Informants and Time

      Innamorati, Marco (2018-07-31)
      There are numerous empirical studies demonstrating that agreement between parent-reports of youth and youth self-reports of internalizing behavior problems is modest at best. This has spurred much research on factors that influence the magnitude of associations between informants, including individual difference characteristics of the informants and contexts through which individuals interact with the child. There is also tremendous interest in understanding symptom trajectories longitudinally. However, each of these lines of work are predicated on the assumptions that the psychometric construct that is being assessed from each informant and at each measurement occasion is the same. This study examined measurement invariance between maternal and child reports and longitudinally across ages 9 and 12 on five dimensions of anxiety using the Screen for Child Anxiety and Related Disorders (SCARED; Birmaher et al., 1999). No cross-informant models for anxiety dimensions achieved acceptable fit and at least partial metric and scalar invariance. Moreover, few longitudinal models demonstrated acceptable fit and at least partial metric and scalar invariance. Thus, using the SCARED as an example, these results show that inter-informant agreement may be compromised by different item functioning, and highlight the need for testing invariance before using measures for longitudinal tracking of symptoms.
    • Magnesium diboride coated bulk niobium: a new approach to higher acceleration gradient

      Tan, Teng; Wolak, Matthäus A.; Xi, X. X.; Tajima, T.; Civale, L. (2016-10-24)
      Bulk niobium Superconducting Radio-Frequency cavities are a leading accelerator technology. Their performance is limited by the cavity loss and maximum acceleration gradient, which are negatively affected by vortex penetration into the superconductor when the peak magnetic field at the cavity wall surface exceeds the vortex penetration field (Hvp). It has been proposed that coating the inner wall of an SRF cavity with superconducting thin films increases Hvp. In this work, we utilized Nb ellipsoid to simulate an inverse SRF cavity and investigate the effect of coating it with magnesium diboride layer on the vortex penetration field. A significant enhancement of Hvp was observed. At 2.8K, Hvp increased from 2100Oe for an uncoated Nb ellipsoid to 2700Oe for a Nb ellipsoid coated with ~200nm thick MgB2 thin film. This finding creates a new route towards achieving higher acceleration gradient in SRF cavity accelerator beyond the theoretical limit of bulk Nb.
    • MgB2 ultrathin films fabricated by hybrid physical chemical vapor deposition and ion milling

      Acharya, Narendra; Wolak, Matthäus A.; Tan, Teng; Lee, Namhoon; Lang, Andrew C.; Taheri, Mitra; Cunnane, Dan; Karasik, Boris S.; Xi, X. X.; 0000-0003-2297-2321 (2016-08-29)
      In this letter, we report on the structural and transport measurements of ultrathin MgB2 films grown by hybrid physical-chemical vapor deposition followed by low incident angle Ar ion milling. The ultrathin films as thin as 1.8 nm, or 6 unit cells, exhibit excellent superconducting properties such as high critical temperature (Tc) and high critical current density (Jc). The results show the great potential of these ultrathin films for superconducting devices and present a possibility to explore superconductivity in MgB2 at the 2D limit.
    • Multi-trophic native and non-native prey naïveté shape marine invasion success

      Eklöv, Peter (2019-09-06)
      Invasive predators have caused rapid declines in many native prey species across the globe. Predator invasion success may be attributed to prey naïvete´, or the absence of antipredator behavior between native and non-native species. An understanding of the effects of naïvete´ at different timescales since introduction and across multiple trophic levels is lacking, however, particularly in marine systems. Given the central role of trophic interactions in invasion dynamics, this knowledge gap limits the ability to predict high impact predator invasions. Naïvete´ was examined across three trophic levels of marine invertebrates: a native basal prey (hard clam), two non-native intermediate predators (the recently-introduced Asian shore crab and the long-established European green crab), a native intermediate predator (juvenile blue crabs), and a native top predator (adult blue crab). We hypothesized that naïvete´ would be more pronounced in trophic interactions involving the recently-introduced non-native predator in comparison to the long-established non-native and native intermediate predators. We further hypothesized that the recently-introduced intermediate predator would both benefit from naïvete´ of the native basal prey and be hindered by higher mortality through its own naïvete´ to the native top predator. To test these hypotheses, three laboratory experiments and a field experiment were used. Consistent with our hypotheses, basal prey naïvete´ was most pronounced with the recently-introduced intermediate predator, and this increased the predator’s foraging success. This recently-introduced intermediate predator, however, exhibited an ineffective anti-predator response to the native top predator, and was also preyed upon more in the field than its long-established and native counterparts. Therefore, despite direct benefits from basal prey naïvete´, the recently-introduced intermediate predator’s naïvete´ to its own predators may limit its invasion success. These results highlight the importance of a multi-trophic perspective on predator-prey dynamics to more fully understand the consequences of naïvete´ in invasion biology.
    • Music interventions for acquired brain injury (Review)

      Magee, Wendy L.; Clark, Imogen; Tamplin, Jeanette; Bradt, Joke; Magee|0000-0003-4350-1289 (2017-01-20)
      Background: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI. Objectives: To assess the effects of music interventions for functional outcomes in people with ABI. We expanded the criteria of our existing review to: 1) examine the efficacy of music interventions in addressing recovery in people with ABI including gait, upper extremity function, communication, mood and emotions, cognitive functioning, social skills, pain, behavioural outcomes, activities of daily living, and adverse events; 2) compare the efficacy of music interventions and standard care with a) standard care alone, b) standard care and placebo treatments, or c) standard care and other therapies; 3) compare the efficacy of different types of music interventions (music therapy delivered by trained music therapists versus music interventions delivered by other professionals). Search methods: We searched the Cochrane Stroke Group Trials Register (January 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (2015, Issue 6), MEDLINE (1946 to June 2015), Embase (1980 to June 2015), CINAHL (1982 to June 2015), PsycINFO (1806 to June 2015), LILACS (1982 to January 2016), and AMED (1985 to June 2015). We handsearched music therapy journals and conference proceedings, searched dissertation and specialist music databases, trials and research registers, reference lists, and contacted relevant experts and music therapy associations to identify unpublished research. We imposed no language restriction. We performed the original search in 2009. Selection criteria: We included all randomised controlled trials and controlled clinical trials that compared music interventions and standard care with standard care alone or combined with other therapies. We examined studies that included people older than 16 years of age who had ABI of a non‐degenerative nature and were participating in treatment programmes offered in hospital, outpatient, or community settings. We included studies in any language, published and unpublished. Data collection and analysis: Two review authors independently extracted data and assessed the risk of bias of the included studies. We contacted trial researchers to obtain missing data or for additional information when necessary. Where possible, we presented results for continuous outcomes in meta‐analyses using mean differences (MDs) and standardised mean differences (SMDs). We used post‐test scores. In cases of significant baseline difference, we used change scores. We conducted a sensitivity analysis to assess the impact of the randomisation method. Main results: We identified 22 new studies for this update. The evidence for this update is based on 29 trials involving 775 participants. A music intervention known as rhythmic auditory stimulation may be beneficial for improving the following gait parameters after stroke. We found a reported increase in gait velocity of 11.34 metres per minute (95% confidence interval (CI) 8.40 to 14.28; 9 trials; 268 participants; P < 0.00001; moderate‐quality evidence). Stride length of the affected side may also benefit, with a reported average of 0.12 metres more (95% CI 0.04 to 0.20; 5 trials; 129 participants; P = 0.003; moderate‐quality evidence). We found a reported average improvement for general gait of 7.67 units on the Dynamic Gait Index (95% CI 5.67 to 9.67; 2 trials; 48 participants; P < 0.00001). There may also be an improvement in gait cadence, with a reported average increase of 10.77 steps per minute (95% CI 4.36 to 17.18; 7 trials; 223 participants; P = 0.001; low‐quality evidence). Music interventions: may be beneficial for improving the timing of upper extremity function after stroke as scored by a reduction of 1.08 seconds on the Wolf Motor Function Test (95% CI ‐1.69 to ‐0.47; 2 trials; 122 participants; very low‐quality evidence). Music interventions may be beneficial for communication outcomes in people with aphasia following stroke. Overall, communication improved by 0.75 standard deviations in the intervention group, a moderate effect (95% CI 0.11 to 1.39; 3 trials; 67 participants; P = 0.02; very low‐quality evidence). Naming was reported as improving by 9.79 units on the Aachen Aphasia Test (95% CI 1.37 to 18.21; 2 trials; 35 participants; P = 0.02). Music interventions may have a beneficial effect on speech repetition, reported as an average increase of 8.90 score on the Aachen Aphasia Test (95% CI 3.25 to 14.55; 2 trials; 35 participants; P = 0.002). There may be an improvement in quality of life following stroke using rhythmic auditory stimulation, reported at 0.89 standard deviations improvement on the Stroke Specific Quality of Life Scale, which is considered to be a large effect (95% CI 0.32 to 1.46; 2 trials; 53 participants; P = 0.002; low‐quality evidence). We found no strong evidence for effects on memory and attention. Data were insufficient to examine the effect of music interventions on other outcomes. The majority of studies included in this review update presented a high risk of bias, therefore the quality of the evidence is low. Authors' conclusions: Music interventions may be beneficial for gait, the timing of upper extremity function, communication outcomes, and quality of life after stroke. These results are encouraging, but more high‐quality randomised controlled trials are needed on all outcomes before recommendations can be made for clinical practice.
    • Neuroethics of Non-primary Brain Computer Interface: Focus on Potential Military Applications

      Machado, Andre (2018-10-23)
      The field of neuroethics has had to adapt rapidly in the face of accelerating technological advancement; a particularly striking example is the realm of Brain-Computer Interface (BCI). A significant source of funding for the development of new BCI technologies has been the United States Department of Defense, and while the predominant focus has been restoration of lost function for those wounded in battle, there is also significant interest in augmentation of function to increase survivability, coordination, and lethality of US combat forces. While restoration of primary motor and sensory function (primary BCI) has been the main focus of research, there has been marked progress in interface with areas of the brain subserving memory and association. Non-Primary BCI has a different subset of potential applications, each of which also carries its own ethical considerations. Given the amount of BCI research funding coming from the Department of Defense, it is particularly important that potential military applications be examined from a neuroethical standpoint.
    • On Objects, Trauma, and Loss: An Interview with Laura Levitt

      Handelman, Kali; Levitt, Laura S. (2021-02-04)