• A call to action: Documenting and sharing solutions and adaptations in sexual, reproductive, maternal and newborn health care provision during the COVID-19 pandemic

      Benova, Lenka; Sarkar, Nandini D. P.; Fasehun, Luther-King; Semaan, Aline; Affun-Adegbulu, Clara; 0000-0002-8798-5433 (2020-10-19)
    • A Clearer Picture: Journalistic identity practices in words and images on Twitter

      Lough, Kyser; Molyneux, Logan; Holton, Avery E.; 0000-0001-7382-3065 (2017-10-27)
      As journalists continue integrating social media into their professional work, they wrestle with ways to best represent themselves, their organizations, and their profession. Several recent studies have examined this trend in terms of branding, raising important questions about the changing ways in which journalists present themselves and how these changes may indicate shifts in their personal and professional identities. This study combines a visual content analysis of the images journalists use in their Twitter profiles with analyses of their profile text and tweets to examine how journalists present themselves online with an eye toward individual and organizational branding. Findings indicate journalists choose a branding approach and apply it consistently across their profiles, with most profiles consisting of a professional headshot while notably lacking organizational identifiers such as logos. Journalists also tend to lean toward professional rather than personal images in their profile and header photographs, indicating a possible predilection for professional identity over personal on social media.
    • A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)

      LIBERATE Study Group (2018-05-22)
      Rationale: This is the first multicenter randomized controlled trial to evaluate the effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little to no collateral ventilation out to 12 months. Objectives: To evaluate the effectiveness and safety of Zephyr EBV in heterogeneous emphysema with little to no collateral ventilation in the treated lobe. Methods: Subjects were enrolled with a 2:1 randomization (EBV/standard of care [SoC]) at 24 sites. Primary outcome at 12 months was the ΔEBV–SoC of subjects with a post-bronchodilator FEV1 improvement from baseline of greater than or equal to 15%. Secondary endpoints included absolute changes in post-bronchodilator FEV1, 6-minute-walk distance, and St. George’s Respiratory Questionnaire scores. Measurements and Main Results: A total of 190 subjects (128 EBV and 62 SoC) were randomized. At 12 months, 47.7% EBV and 16.8% SoC subjects had a ΔFEV1 greater than or equal to 15% (P < 0.001). ΔEBV–SoC at 12 months was statistically and clinically significant: for FEV1, 0.106 L (P < 0.001); 6-minute-walk distance, +39.31 m (P = 0.002); and St. George’s Respiratory Questionnaire, −7.05 points (P = 0.004). Significant ΔEBV–SoC were also observed in hyperinflation (residual volume, −522 ml; P < 0.001), modified Medical Research Council Dyspnea Scale (−0.8 points; P < 0.001), and the BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index (−1.2 points). Pneumothorax was the most common serious adverse event in the treatment period (procedure to 45 d), in 34/128 (26.6%) of EBV subjects. Four deaths occurred in the EBV group during this phase, and one each in the EBV and SoC groups between 46 days and 12 months. Conclusions: Zephyr EBV provides clinically meaningful benefits in lung function, exercise tolerance, dyspnea, and quality of life out to at least 12 months, with an acceptable safety profile in patients with little or no collateral ventilation in the target lobe. Clinical trial registered with www.clinicaltrials.gov (NCT 01796392).
    • Aggregation, Clickbait and Their Effect on Perceptions of Journalistic Credibility and Quality

      Molyneux, Logan; Coddington, Mark; 0000-0001-7382-3065 (2019-06-16)
      Many journalists and industry observers lament that aggregating news underneath sensational headlines will erode credibility and turn off readers. While some scholarly work has studied journalists’ perspectives of this practice, little has been done to understand what audiences think of aggregation and clickbait. This study uses published original and aggregated news articles as stimuli in two online experiments to test readers’ perceptions of news aggregation and clickbait. Aggregation itself has little effect on perceptions of credibility and quality; instead, writing proficiency is more closely linked to these perceptions. Results also suggest clickbait headlines may lower perceptions of credibility and quality.
    • Air Current Applied to the Face Improves Exercise Performance in Patients with COPD

      Marchetti, Nathaniel; Lammi, Matthew R.; Travaline, John M.; Ciccolella, David; Civic, Brian; Criner, Gerard J. (2015-08-09)
      Purpose: Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. Methods: We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3 % predicted), TLC 107 ± 6 %, RV 172 ± 18 %) naïve to the study hypothesis. Each patient was randomized in a crossover fashion to lower extremity ergometry at constant submaximal workload with a 12-diameter fan directed at the patients face or exposed leg. Each patients’ studies were separated by at least 1 week. Inspiratory capacity and Borg dyspnea score were measured every 2 min and at maximal exercise. Results: Total exercise time was longer when the fan was directed to the face (14.3 ± 12 vs. 9.4 ± 7.6 min, face vs. leg, respectively, p = 0.03). Inspiratory capacity tended to be greater with the fan directed to the face (1.4 (0.6–3.25) vs. 1.26 (0.56–2.89) L, p = 0.06). There was a reduction in dynamic hyperinflation, as reflected by higher IRV area in the fan on face group (553 ± 562 a.u. vs. 328 ± 319 a.u., p = 0.047). There was a significant improvement in the Borg dyspnea score at maximal exercise (5.0 (0–10) vs. 6.5 (0–10), p = 0.03), despite exercising for 34 % longer with the fan directed to the face. Conclusions: Air current applied to the face improves exercise performance in COPD. Possible mechanisms include an alteration in breathing pattern that diminishes development of dynamic hyperinflation or to a change in perception of breathlessness.
    • Body Image and Quality of Life in Adolescents With Craniofacial Conditions

      Crerand, Canice E.; Sarwer, David; Kazak, Anne E.; Clarke, Alexandra; Rumsey, Nichola; 0000-0003-1033-5528 (2016-01-11)
      Objective: To evaluate body image in adolescents with and without craniofacial conditions and to examine relationships between body image and quality of life. Design: Case-control design. Setting: A pediatric hospital's craniofacial center and primary care practices. Participants: Seventy adolescents with visible craniofacial conditions and a demographically matched sample of 42 adolescents without craniofacial conditions. Main Outcome Measure: Adolescents completed measures of quality of life and body image including satisfaction with weight, facial and overall appearance, investment in appearance (importance of appearance to self-worth), and body image disturbance (appearance-related distress and impairment in functioning). Results: Adolescents with craniofacial conditions reported lower appearance investment (P < .001) and were more likely to report concerns about facial features (P < .02) compared with nonaffected youth. Females in both groups reported greater investment in appearance, greater body image disturbance, and lower weight satisfaction compared with males (P < .01). Within both groups, greater body image disturbance was associated with lower quality of life (P < .01). The two groups did not differ significantly on measures of quality of life, body image disturbance, or satisfaction with appearance. Conclusions: Body image and quality of life in adolescents with craniofacial conditions are similar to nonaffected youth. Relationships between body image and quality of life emphasize that appearance perceptions are important to adolescents’ well-being regardless of whether they have a facial disfigurement. Investment in one's appearance may explain variations in body image satisfaction and serve as an intervention target, particularly for females.
    • Book Review: Larry May and Shannon Fyfe, International Criminal Tribunals: A Normative Defense

      deGuzman, Margaret M. (2018-06-08)
      In "International Criminal Tribunals: A Normative Defense," Larry May and Shannon Fyfe set out to demonstrate that international tribunals provide “the fairest way to deal with mass atrocity crimes in a global arena.” To do so, the authors take up a wide range of critiques that scholars and others have leveled at international criminal tribunals and argue that although most have some validity, none are fatal to the enterprise of international criminal justice. The authors’ analysis of the various critiques yields both normative arguments about the value of international criminal tribunals and suggestions about how the institutions can be improved. In advancing their normative claims and supporting their prescriptive suggestions, the authors draw on a deep well of philosophical and theoretical concepts, including legitimacy, fairness, effectiveness, and efficiency. The result is a book that not only canvases and addresses the broad array of critiques leveled at international criminal tribunals but adds significantly to the rather scant literature on the philosophical justifications for international criminal justice.
    • Branding (Health) Journalism: Perceptions, practices, and emerging norms

      Molyneux, Logan; Holton, Avery E.; 0000-0001-7382-3065 (2014-04-30)
      Observational studies of journalists on social media platforms suggest that journalists are beginning to develop personal brands using social media. Similar studies suggest that journalists covering specialty areas such as health are more likely to experiment with and adopt new forms of practice that break with the traditional tenets of journalism. Through interviews with such journalists, this study explores the perceptions, practices, and drivers of personal branding among journalists. Findings indicate journalists are squarely focused on branding at the individual level (rather than branding the organizations they work for). Journalists cite technological and cultural changes in the profession as giving rise to personal branding. They also describe the tension they feel between their obligation to uphold the traditional tenets of journalism and their perceived need to incorporate more branding into their practice, especially on social media platforms. The findings indicate that journalists may be changing the fundamental elements of branding in at least one way, exchanging the differentiation between themselves and their content for the mutual sharing and co-creation of content with their colleagues and audience.
    • Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19

      Center for Metabolic Disease Research (Temple University) (2020-12-10)
      Patients with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID‐19 (Neuro‐SARS2). Accumulated robust evidence indicates that Neuro‐SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro‐SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS‐CoV‐2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro‐SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens.
    • Commentary on: Motivations, Expectations, and Experiences of Labiaplasty: A Qualitative Study

      Center for Obesity Research and Education (Temple University) (2016-04-12)
    • Concise Syntheses of bis‐Strychnos Alkaloids (−)‐Sungucine, (−)‐Isosungucine, and (−)‐Strychnogucine B from (−)‐Strychnine

      Zhao, Senzhi; Chen, Heng; Sirasani, Gopal; Dobereiner, Graham; Andrade, Rodrigo B.; Teijaro, Christiana; Vaddypally, Shivaiah; Zdilla, Michael; 0000-0001-5375-0241; 0000-0001-6203-9689; 0000-0003-0212-2557; 0000-0001-6885-2021 (2016-06-15)
      The first chemical syntheses of complex, bis‐Strychnos alkaloids (−)‐sungucine (1), (−)‐isosungucine (2), and (−)‐strychnogucine B (3) from (−)‐strychnine (4) is reported. Key steps included (1) the Polonovski–Potier activation of strychnine N‐oxide; (2) a biomimetic Mannich coupling to forge the signature C23−C5′ bond that joins two monoterpene indole monomers; and (3) a sequential HBr/NaBH3CN‐mediated reduction to fashion the ethylidene moieties in 1–3. DFT calculations were employed to rationalize the regiochemical course of reactions involving strychnine congeners.
    • Duolingo English Test, Revised Version July 2019

      Wagner, Elvis; 0000-0003-2332-3323 (2020-06-28)
      The Duolingo English Test (DET) is a computer adaptive test of English proficiency that is increasingly used for English-medium university admissions purposes. During the COVID-19 pandemic of 2020, test centers were shut down in many countries, and major tests including the TOEFL iBT and IELTS could not be administered. The DET is an “at home” test, and thus many universities began accepting DET scores as ameasure of applicants’ English proficiency. Because a revised version of the DET was launched in July, 2019, and because of the large increase in universities accepting DET scores, a critical review of the DET is warranted. The current review lauds the accessibility of the test (e.g., it is an inexpensive “at home” test that can be taken anywhere, in less than an hour, with scores returned in 48 hours). However, the test has multiple shortcomings: the test tasks have little in common with the types of language tasks university students engage in; the test does not assess test takers’ academic language ability, discourse level competence, or interactional competence; it is susceptible to cheating and test preparation; and it has a potential for negative washback on learners and learning systems. In addition, there is a lack of independent research validating the use of DET scores for admissions. Given these shortcomings, the use of DET scores cannot be recommended for university admissions purposes.
    • Experimental Investigations on the Basis for Intellectual Property Rights

      Fast, Anne A.; Olson, Kristina R.; Mandel, Gregory N. (2016-05-05)
      Lay people routinely misunderstand or do not obey laws protecting intellectual property (IP), leading to a variety of (largely unsuccessful) efforts by policymakers, IP owners, and researchers to change those beliefs and behaviors. The current work tests a new approach, inquiring whether lay people’s views about IP protection can be modified by arguments concerning the basis for IP rights. Across 2 experiments, 572 adults (recruited through Amazon Mechanical Turk) read 1 of 6 arguments about the basis for IP protection (incentives, natural rights, expressive rights, plagiarism, commons, or no argument). Participants then reported their general support for IP protection. Participants also reported their evaluations of 2 scenarios that involved infringement of IP rights, including cases in which there were mitigating experiences (e.g., the copier acknowledged the original source), and completed several demographic questions. Three primary findings emerged: (a) exposure to the importance of the public commons (and to a lesser extent, exposure to the argument that plagiarism is the basis of IP protection) led participants to become less supportive of IP protection than the incentives, natural rights, expressive rights, and control conditions; (b) people believed that infringement was more acceptable if the infringer acknowledged the original creator of the work; and (c) older adults and women were especially likely to see infringement as problematic. These findings illustrate several ways in which lay beliefs are at odds with legal doctrine, and suggest that people’s views about IP protection can be shaped in certain ways by learning the basis for IP rights.
    • How journalists engage in branding on Twitter: individual, organizational, and institutional levels

      Molyneux, Logan; Holton, Avery E.; Lewis, Seth C.; 0000-0001-7382-3065 (2017-04-18)
      In a social media age, branding is an increasingly visible aspect of identity construction online. For media professionals generally and journalists especially, branding on spaces such as Twitter reveals the complicated set of forces confronting such public-facing actors as they navigate tensions between personal disclosure for authenticity and professional decorum for credibility, and between establishing one’s own distinctiveness and promoting one’s employer or other stakeholders. While studies have begun to reveal what journalists say about branding, they have yet to provide a broad profile of what they do. This study takes up that challenge through a content analysis of the Twitter profiles and tweets of a representative sample of 384 U.S. journalists. We focus on the extent of branding practices; the levels at which such branding occurs, whether to promote one’s self (individual), one’s news organization (organizational), or the journalism profession at large (institutional); and how other social media practices may be related to forms of journalistic branding. Results suggest that branding is now widely common among journalists on Twitter; that branding occurs at all three levels but primarily at the individual and organizational levels, with organizational branding taking priority; and that time on Twitter is connected with more personal information being shared.
    • Law's Guilt about Literature

      Baron, Jane B. (2005-06-06)
      This essay addresses the theme of guilt in law and literature from the law side. It argues that the legal academy's flirtation with literature reflects two forms of guilty uneasiness. The first relates to the question whether lawyers should be reading literature at all. This is a methodological anxiety. It presumes a distinctly legal method of analyzing legal issues, in which literature does not have a truly legitimate role. The second anxiety is substantive. It presumes that law has an identifiable content, one that excludes much that appears in literature. Both presumptions are, I argue, questionable and make sense only if law is viewed as primarily doctrinal. Fundamentally, these varieties of uneasiness have their roots in the still unresolved conceptual challenge of figuring precisely what is “interdisciplinary” about the law and literature enterprise. Developing an honest form of “interdisciplinarity” will be difficult if not impossible because it requires an examination of usually unstated assumptions about the uniqueness of law.
    • Mobile News Consumption: A Habit of Snacking

      Molyneux, Logan; 0000-0001-7382-3065 (2017-06-16)
      This study investigates news consumption on mobile devices with the goal of identifying where mobile devices fit into people’s media repertoires and how consumption patterns on them are different from those on other platforms. Results suggest that mobile devices are almost always used along with other platforms for getting news, that news sessions on smartphones are shorter than on other platforms, and mobile news consumption happens more times per day and is spread throughout the day. Implications for the study of news consumption, news producers, and consumers are discussed.
    • Mobilization and Preparation of a Large Urban Academic Center During the COVID-19 Pandemic

      Chowdhury, Junad M.; Patel, Maulin; Zheng, Matthew; Abramian, Osheen; Criner, Gerard J. (2020-04-21)