• A meta-analytic review of the relationship of cancer coping selfefficacy with distress and quality of life

      Chirico, A; Lucidi, F; Merluzzi, T; Alivernini, F; Laurentiis, MD; Botti, G; Giordano, A; Giordano, Antonio|0000-0002-5959-016X (2017-02-27)
      © Chirico et al. Self-efficacy for coping with cancer is a specific construct that refers to behaviors that occur in the course of dealing with a cancer diagnosis, cancer treatments, and transitioning to survivorship. One of the more widely used measures of self-efficacy for coping strategies with cancer is the Cancer Behavior Inventory. The following general questions provide a framework for this research: 1. Is self-efficacy for coping with cancer related to distress and quality of life of a cancer patient?. 2. Do self-efficacy for coping with cancer and the target psychological outcomes (i.e., distress and quality of life) change in longitudinal studies, with or without intervention? One-hundred eighty studies cited the different versions of the Cancer Behavior Inventory and 47 used the scale. Result showed an inverse relationship between self-efficacy for coping with cancer and distress, and a positive relationship between self-efficacy for coping with cancer and Quality of Life, both with a large effect size. The strong relationship of self-efficacy and outcomes, resulted of the specificity of the instrument, which targets specific coping strategies that are closely aligned with positive outcomes in adjusting to cancer. However, the results are consistent with the theory, which states that compared to those with low efficacy, highly efficacious people demonstrate less anxiety and better adjustment in stressful situations and consistent with prior results in which self-efficacy is positively related to quality of life.
    • A nuclear mtDNA concatemer (Mega-NUMT) could mimic paternal inheritance of mitochondrial genome

      Balciuniene, J; Balciunas, D; Balciunas, Darius|0000-0003-1938-3243 (2019-01-01)
    • Accessing the inaccessible: Redefining play as a spectrum

      Zosh, JM; Hirsh-Pasek, K; Hopkins, EJ; Jensen, H; Liu, C; Neale, D; Solis, SL; Whitebread, D (2018-08-02)
      © 2018 Zosh, Hirsh-Pasek, Hopkins, Jensen, Liu, Neale, Solis and Whitebread. Defining play has plagued researchers and philosophers for years. From describing play as an inaccessible concept due to its complexity, to providing checklists of features, the field has struggled with how to conceptualize and operationalize "play." This theoretical piece reviews the literature about both play and learning and suggests that by viewing play as a spectrum - that ranges from free play (no guidance or support) to guided play and games (including purposeful adult support while maintaining playful elements), we better capture the true essence of play and explain its relationship to learning. Insights from the Science of Learning allow us to better understand why play supports learning across social and academic domains. By changing the lens through which we conceptualize play, we account for previous findings in a cohesive way while also proposing new avenues of exploration for the field to study the role of learning through play across age and context.
    • Aging of the inceptive cellular population: the relationship between stem cells and aging.

      Symonds, CE; Galderisi, U; Giordano, A; Giordano, Antonio|0000-0002-5959-016X (2009-01-01)
      The average life expectancy worldwide has about doubled and the global population has increased six fold over the past century. With improving health care in the developed world there is a proportional augmentation in the treatment necessary for elderly patients occasioning the call for increased research in the area of aging and age-related diseases. The manifestation of this research has been focalized on the causative cellular processes and molecular mechanisms involved. Here we will discuss the efforts of this research in the area of stem cells, delving into the regulatory mechanisms and how their de-regulation could be attributed to aging and age-related diseases.
    • Amniote phylogeny and the position of turtles

      Hedges, SB (2012-07-27)
      The position of turtles among amniotes remains in dispute, with morphological and molecular comparisons giving different results. Morphological analyses align turtles with either lizards and their relatives, or at the base of the reptile tree, whereas molecular analyses, including a recent study by Chiari et al. in BMC Biology, place turtles with birds and crocodilians. Molecular studies have not wavered as the numbers of genes and species have increased, but morphologists have been reluctant to embrace the molecular tree.Please see Research article www.biomedcentral.com/1741-7007/10/65. © 2012 Hedges; licensee BioMed Central Ltd.
    • Array programming with NumPy

      Harris, CR; Millman, KJ; van der Walt, SJ; Gommers, R; Virtanen, P; Cournapeau, D; Wieser, E; Taylor, J; Berg, S; Smith, NJ; Kern, R; Picus, M; Hoyer, S; van Kerkwijk, MH; Brett, M; Haldane, A; del Río, JF; Wiebe, M; Peterson, P; Gérard-Marchant, P; Sheppard, K; Reddy, T; Weckesser, W; Abbasi, H; Gohlke, C; Oliphant, TE (2020-09-17)
      © 2020, The Author(s). Array programming provides a powerful, compact and expressive syntax for accessing, manipulating and operating on data in vectors, matrices and higher-dimensional arrays. NumPy is the primary array programming library for the Python language. It has an essential role in research analysis pipelines in fields as diverse as physics, chemistry, astronomy, geoscience, biology, psychology, materials science, engineering, finance and economics. For example, in astronomy, NumPy was an important part of the software stack used in the discovery of gravitational waves1 and in the first imaging of a black hole2. Here we review how a few fundamental array concepts lead to a simple and powerful programming paradigm for organizing, exploring and analysing scientific data. NumPy is the foundation upon which the scientific Python ecosystem is constructed. It is so pervasive that several projects, targeting audiences with specialized needs, have developed their own NumPy-like interfaces and array objects. Owing to its central position in the ecosystem, NumPy increasingly acts as an interoperability layer between such array computation libraries and, together with its application programming interface (API), provides a flexible framework to support the next decade of scientific and industrial analysis.
    • BGEM: An in situ hybridization database of gene expression in the embryonic and adult mouse nervous system

      Magdaleno, S; Jensen, P; Brumwell, CL; Seal, A; Lehman, K; Asbury, A; Cheung, T; Cornelius, T; Batten, DM; Eden, C; Norland, SM; Rice, DS; Dosooye, N; Shakya, S; Mehta, P; Curran, T (2006-01-01)
    • Biogeography and potential exchanges among the atlantic equatorial belt cold-seep faunas

      Olu, K; Cordes, EE; Fisher, CR; Brooks, JM; Sibuet, M; Desbruyères, D; Cordes, Erik|0000-0002-6989-2348 (2010-10-15)
      Like hydrothermal vents along oceanic ridges, cold seeps are patchy and isolated ecosystems along continental margins, extending from bathyal to abyssal depths. The Atlantic Equatorial Belt (AEB), from the Gulf of Mexico to the Gulf of Guinea, was one focus of the Census of Marine Life ChEss (Chemosynthetic Ecosystems) program to study biogeography of seep and vent fauna. We present a review and analysis of collections from five seep regions along the AEB: the Gulf of Mexico where extensive faunal sampling has been conducted from 400 to 3300m, the Barbados accretionary prism, the Blake ridge diapir, and in the Eastern Atlantic from the Congo and Gabon margins and the recently explored Nigeria margin. Of the 72 taxa identified at the species level, a total of 9 species or species complexes are identified as amphi-Atlantic. Similarity analyses based on both Bray Curtis and Hellinger distances among 9 faunal collections, and principal component analysis based on presence/absence of megafauna species at these sites, suggest that within the AEB seep megafauna community structure is influenced primarily by depth rather than by geographic distance. Depth segregation is observed between 1000 and 2000m, with the middle slope sites either grouped with those deeper than 2000m or with the shallower sites. The highest level of community similarity was found between the seeps of the Florida escarpment and Congo margin. In the western Atlantic, the highest degree of similarity is observed between the shallowest sites of the Barbados prism and of the Louisiana slope. The high number of amphi-atlantic cold-seep species that do not cluster according to biogeographic regions, and the importance of depth in structuring AEB cold-seep communities are the major conclusions of this study. The hydrothermal vent sites along the Mid Atlantic Ridge (MAR) did not appear as"stepping stones" for dispersal of the AEB seep fauna, however, the south MAR and off axis regions should be further explored to more fully test this hypothesis.© 2010 Olu et al.
    • Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

      Silbermann, R; Bolzoni, M; Storti, P; Guasco, D; Bonomini, S; Zhou, D; Wu, J; Anderson, JL; Windle, JJ; Aversa, F; David Roodman, G; Giuliani, N (2014-01-01)
    • Caregiving, intellectual disability, and dementia: Report of the Summit Workgroup on Caregiving and Intellectual and Developmental Disabilities

      Heller, T; Scott, HM; Janicki, MP; Esbensen, A; Fazio, S; Yoshizaki-Gibbons, H; Hartley, DH; Jokinen, N; Kallmyer, B; Keller, S; Magana, S; Marsack, C; McCallion, P; Perkins, E; Putnam, M; Qualls, S; Rader, R; Roberto, K; Wheeler, B; Mccallion, Philip|0000-0001-5129-6399 (2018-01-01)
      © 2018 Introduction: A specially commissioned working group produced a report on caregiving, intellectual and developmental disabilities (IDDs), and dementia for the National Institutes of Health–located National Research Summit on Care, Services, and Supports for Persons with Dementia and Their Caregivers. Methods: Experts in caregiving, dementia, and IDDs examined the current state of research, policy, and practice related to caregiving and supports; identified the similarities and dissimilarities between IDD-related care and services and the general population affected by dementia; and considered how these findings might contribute to the conversation on developing a dementia care research and services development agenda. Results: Five major areas related to programs and caregiving were assessed: (1) challenges of dementia; (2) family caregiving interventions; (3) supportive care settings; (4) effects of diversity; and (5) bridging service networks of aging and disability. Discussion: Recommendations included increasing supports for caregivers of adults with IDDs and dementia; increasing research on community living settings and including caregivers of persons with IDDs in dementia research; acknowledging cultural values and practice diversity in caregiving; increasing screening for dementia and raising awareness; and leveraging integration of aging and disability networks.
    • Casting a wider net: Differentiating between inner nuclear envelope and outer nuclear envelope transmembrane proteins

      Tingey, M; Mudumbi, KC; Schirmer, EC; Yang, W; Yang, Weidong|0000-0002-3554-3035 (2019-11-01)
      © 2019 by the authors. Licensee MDPI, Basel, Switzerland. The nuclear envelope (NE) surrounds the nucleus with a double membrane in eukaryotic cells. The double membranes are embedded with proteins that are synthesized on the endoplasmic reticulum and often destined specifically for either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM). These nuclear envelope transmembrane proteins (NETs) play important roles in cellular function and participate in transcription, epigenetics, splicing, DNA replication, genome architecture, nuclear structure, nuclear stability, nuclear organization, and nuclear positioning. These vital functions are dependent upon both the correct localization and relative concentrations of NETs on the appropriate membrane of the NE. It is, therefore, important to understand the distribution and abundance of NETs on the NE. This review will evaluate the current tools and methodologies available to address this important topic.
    • CDK9 inhibitors in acute myeloid leukemia

      Boffo, S; Damato, A; Alfano, L; Giordano, A; Boffo, Silvia|0000-0002-6352-160X; Giordano, Antonio|0000-0002-5959-016X (2018-02-23)
      © 2018 The Author(s). Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and rational combinations. Targeting the cyclin-dependent kinase 9 (CDK9) pathway, which is dysregulated in AML, is an attractive approach. Inhibition of CDK9 leads to downregulation of cell survival genes regulated by super enhancers such as MCL-1, MYC, and cyclin D1. As CDK9 inhibitors are nonselective, predictive biomarkers that may help identify patients most likely to respond to CDK9 inhibitors are now being utilized, with the goal of improving efficacy and safety.
    • Challenges in microbial ecology: Building predictive understanding of community function and dynamics

      Widder, S; Allen, RJ; Pfeiffer, T; Curtis, TP; Wiuf, C; Sloan, WT; Cordero, OX; Brown, SP; Momeni, B; Shou, W; Kettle, H; Flint, HJ; Haas, AF; Laroche, B; Kreft, JU; Rainey, PB; Freilich, S; Schuster, S; Milferstedt, K; Van Der Meer, JR; Grobkopf, T; Huisman, J; Free, A; Picioreanu, C; Quince, C; Klapper, I; Labarthe, S; Smets, BF; Wang, H; Soyer, OS; Allison, SD; Chong, J; Lagomarsino, MC; Croze, OA; Hamelin, J; Harmand, J; Hoyle, R; Hwa, TT; Jin, Q; Johnson, DR; de Lorenzo, V; Mobilia, M; Murphy, B; Peaudecerf, F; Prosser, JI; Quinn, RA; Ralser, M; Smith, AG; Steyer, JP; Swainston, N; Tarnita, CE; Trably, E; Warren, PB; Wilmes, P (2016-11-01)
      © 2016 International Society for Microbial Ecology All rights reserved. The importance of microbial communities (MCs) cannot be overstated. MCs underpin the biogeochemical cycles of the earth's soil, oceans and the atmosphere, and perform ecosystem functions that impact plants, animals and humans. Yet our ability to predict and manage the function of these highly complex, dynamically changing communities is limited. Building predictive models that link MC composition to function is a key emerging challenge in microbial ecology. Here, we argue that addressing this challenge requires close coordination of experimental data collection and method development with mathematical model building. We discuss specific examples where model-experiment integration has already resulted in important insights into MC function and structure. We also highlight key research questions that still demand better integration of experiments and models. We argue that such integration is needed to achieve significant progress in our understanding of MC dynamics and function, and we make specific practical suggestions as to how this could be achieved.
    • Child/Adolescent Anxiety Multimodal Study (CAMS): Rationale, design, and methods

      Compton, SN; Walkup, JT; Albano, AM; Piacentini, JC; Birmaher, B; Sherrill, JT; Ginsburg, GS; Rynn, MA; McCracken, JT; Waslick, BD; Iyengar, S; Kendall, PC; March, JS (2010-01-05)
      Objective: To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents.Methods: Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described.Results: CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance.Conclusions: CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders.Trial registration: ClinicalTrials.gov NCT00052078. © 2010 Compton et al; licensee BioMed Central Ltd.
    • Comparison of immunogen designs that optimize peptide coverage: Reply to Fischer et al. [2]

      Nickle, DC; Jojic, N; Heckerman, D; Jojic, V; Kirovski, D; Rolland, M; Pond, SK; Mullins, JI; Pond, Sergei L. Kosakovsky|0000-0003-4817-4029 (2008-01-01)
    • Connecting brain responsivity and real-world risk taking: Strengths and limitations of current methodological approaches

      Sherman, L; Steinberg, L; Chein, J (2018-10-01)
      © 2017 The Authors In line with the goal of limiting health risk behaviors in adolescence, a growing literature investigates whether individual differences in functional brain responses can be related to vulnerability to engage in risky decision-making. We review this body of work, investigate when and in what way findings converge, and provide best practice recommendations. We identified 23 studies that examined individual differences in brain responsivity and adolescent risk taking. Findings varied widely in terms of the neural regions identified as relating to risky behavior. This heterogeneity is likely due to the abundance of approaches used to assess risk taking, and to the disparity of fMRI tasks. Indeed, brain-behavior correlations were typically found in regions showing a main effect of task. However, results from a test of publication bias suggested that region of interest approaches lacked evidential value. The findings suggest that neural factors differentiating riskier teens are not localized to a single region. Therefore, approaches that utilize data from the entire brain, particularly in predictive analyses, may yield more reliable and applicable results. We discuss several decision points that researchers should consider when designing a study, and emphasize the importance of precise research questions that move beyond a general desire to address adolescent risk taking.
    • Correction: P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma (Cell Death & Disease, (2020), 11, 9, (748), 10.1038/s41419-020-02940-w)

      Costa, C; Indovina, P; Mattioli, E; Forte, IM; Iannuzzi, CA; Luzzi, L; Bellan, C; De Summa, S; Bucci, E; Di Marzo, D; De Feo, M; Mutti, L; Pentimalli, F; Giordano, A; Giordano, Antonio|0000-0002-5959-016X (2020-10-01)
      © 2020, The Author(s). Owing to an error in production, the original version of this Article contained an error in the author affiliations. Author Francesca Pentimalli was incorrectly associated with Histopathological Unit, IRCCS-Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, Italy. The author’s actual affiliation is Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCSFondazione G. Pascale, I-80131 Napoli, Italy. We apologise for this error, and confirm that it this has now been corrected in both the PDF and HTML versions of the Article.
    • Crosstalk between microRNA and oxidative stress in physiology and pathology

      Fioravanti, A; Pirtoli, L; Giordano, A; Dotta, F; Giordano, Antonio|0000-0002-5959-016X (2020-02-01)
      <jats:p>MicroRNAs (miRNA), are short regulatory RNA molecules that regulate gene expression by binding specific sequences within target messenger RNA (mRNA) [...]</jats:p>
    • Curcumin and cancer

      Giordano, A; Tommonaro, G; Giordano, Antonio|0000-0002-5959-016X (2019-10-01)
      © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.