Research Data
http://hdl.handle.net/20.500.12613/7
2024-03-29T05:41:37ZNerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation
http://hdl.handle.net/20.500.12613/9993
Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation
The original design and necessary modifications of the project plan are as described in part 1 of this series (26). The current study is part 4 of a series reports and results from 30 animals with three main groups (Fig. 1A). The ObNT-ScNT Reinn group consisted of 8 dogs that were in the study a total of 22 months (22 ± 0.4 mo, mean ± SEM, Fig. 1B). At study onset, these ObNT-ScNT Reinn animals functionally decentralized by bilaterally transecting the dorsal roots of L7, all spinal roots caudal to L7, and the hypogastric nerves, followed by a 9-13 mo recovery period (10.4 ± 0.7 mo, Fig. 1C), then reinnervation by transfer of the obturator nerve to the vesical branch of the pelvic nerve, as well as a branch of the sciatic nerve to the pudendal nerve, that was then followed by an additional 8-12 mo recovery (11.9 ± 0.4 mo, Fig. 1C). The Decentralized group consisted of 4 animals that underwent similar decentralization followed by an 11-21 mo recovery (18 ± 2.5 mo, Fig. 1B), but no reinnervation surgeries. Controls consists of 7 sham-operated and 11 unoperated animals (18 total; Fig. 1A).
The original design and necessary modifications of the project plan are as described in part 1 of this series (26). The current study is part 4 of a series reports and results from 30 animals with three main groups (Fig. 1A). The ObNT-ScNT Reinn group consisted of 8 dogs that were in the study a total of 22 months (22 ± 0.4 mo, mean ± SEM, Fig. 1B). At study onset, these ObNT-ScNT Reinn animals functionally decentralized by bilaterally transecting the dorsal roots of L7, all spinal roots caudal to L7, and the hypogastric nerves, followed by a 9-13 mo recovery period (10.4 ± 0.7 mo, Fig. 1C), then reinnervation by transfer of the obturator nerve to the vesical branch of the pelvic nerve, as well as a branch of the sciatic nerve to the pudendal nerve, that was then followed by an additional 8-12 mo recovery (11.9 ± 0.4 mo, Fig. 1C). The Decentralized group consisted of 4 animals that underwent similar decentralization followed by an 11-21 mo recovery (18 ± 2.5 mo, Fig. 1B), but no reinnervation surgeries. Controls consists of 7 sham-operated and 11 unoperated animals (18 total; Fig. 1A).
There is some overlap with the pilot study (22) and part 2 (25) of this series. Specifically, we included squat-and-void posture data from 3 ObNT-ScNT Reinn animals, 1 Decentralized animal, and 8 Control animals (5 sham-operated and 3 sham-unoperated) from the small pilot study, and in vivo electrophysiology data for peripheral nerve-evoked bladder, urethra and anal sphincter contractility from 3 ObNT-ScNT Reinn animals from the pilot study (22). We also included the in vivo peripheral nerve-evoked bladder contractility graph from Part 2 of this series (25) for comparison purposes to new additional data.
Unique to this manuscript are: 1) data from 18 additional animals, 2) report of defecation postures; 3) segmental spinal root/cord-evoked bladder, urethra and anal sphincter contractility data from all animals from L2-S3 to more closely match reports that spinal cord input to the obturator nerve is nearer to L3-L6 (20, 27-29); 4) peripheral nerve-evoked urethra and anal sphincter contractility data from the Decentralized and Control animals, and 5 additional ObNT-ScNT Reinn animals; 5) retrograde dye labeling data in the spinal cord ventral horn segments from L2-S3 after dye injections into the bladder and urethra sphincter; 6) Rexed laminar location of these labeled neurons in the spinal cord; and 7) correlations between these various outcomes. Because of the inclusion of the urethral and anal sphincter data, we renamed the reinnervated group to ObNT-ScNT Reinn (different from prior studies in which we focused on the obturator nerve transfer to the pelvic nerve results, and thus named the reinnervated group as “ObNT-Reinn”).
2024-03-01T00:00:00ZPerforming Spirometry and Low Dose Chest CT to Screen for COPD Systematic Review Search Strategy
http://hdl.handle.net/20.500.12613/9700
Performing Spirometry and Low Dose Chest CT to Screen for COPD Systematic Review Search Strategy
To identify studies to include or consider for this systematic review, the review team worked with a librarian (TN) to develop detailed search strategies for each database. The PRISMA-S extension was followed for search reporting. The librarian (TN) developed the search for PubMed (NLM) and translated the search for every database searched. The PubMed (NLM) search strategy was reviewed by the research team to check for accuracy and term relevancy. All final searches were peer-reviewed by another librarian (Jacob Brintzenhoff) following the Peer Review of Electronic Search Strategies (PRESS checklist).
The databases included in this search are PubMed (NLM), Embase (Elsevier), Cochrane Central (Wiley), CINAHL (EbscoHost), and Web of Science (Clarivate Analytics), using a combination of keywords and subject headings. A grey literature search included two clinical trials registries, clinicaltrials.gov and WHO ICTRP (https://trialsearch.who.int/), and the pre-print MedRxiv (https://www.medrxiv.org/). The search was limited to English language and to adults. All final searches were performed on November 17, 2023 by the librarian (TN) and were fully reported on November 21, 2023. The full search strategies as reported by the librarian are provided in Appendix(___). They are also archived at [DOI].
A summary of the search results from databases:
PubMed (NLM) from inception to 11/17/2023 (650 Results)
Embase (Elsevier) from 1974 to 11/17/2023 (1,849 Results)
Cochrane Central (Wiley) from inception to 11/17/2023 (161 Results)
CINAHL (EbscoHost) from 1982 to 11/17/2023 (36 Results)
Web of Science Core Collection (Clarivate Analytics) from inception to 11/17/2023 (416 Results)
The search resulted in 3,347 studies and 961 duplicate studies were found and omitted by the librarian the EndNote 20 and following the Wichor Bramer duplicate identification strategy. This resulted in 3,165 records to screen from databases or registers and 182 records to screen from other methods, resulting in a total of 2,386 records. Studies were screened by title and abstract by two blinded and independent reviewers. If a tiebreaker was needed, a third reviewer was called in. This process was repeated for full text article screening and article selection.
2024-02-20T00:00:00ZPelvic Floor Muscle Training Systematic Review Search Strategy
http://hdl.handle.net/20.500.12613/9260
Pelvic Floor Muscle Training Systematic Review Search Strategy
To identify studies to include or consider for this systematic review, the review team worked with a health sciences librarian (TN) to develop detailed search strategies for each database. The PRISMA-S extension was followed for search reporting. The librarian (TN) developed the search for PubMed (NLM) and translated the search strategy for every database searched. The PubMed (NLM) search strategy was reviewed by the research team to check for accuracy and term relevancy, and all final searches were peer-reviewed by another librarian following the Peer Review of Electronic Search Strategies (PRESS checklist).
2023-12-12T00:00:00ZTraumatic Bereavement and Healing Meta-Synthesis Search Strategy
http://hdl.handle.net/20.500.12613/9259
Traumatic Bereavement and Healing Meta-Synthesis Search Strategy
The databases included in this search are PubMed (NLM), PsycInfo (EbscoHost), CINAHL (EbscoHost), Academic Search Complete (Ebscohost), and Web of Science (Clarivate Analytics) using a combination of keywords and subject headings. A grey literature search included TRIP Pro medical database (tripdatabase.com) website and BioPreprint (https://www.hsls.pitt.edu/). The search was limited to adults, qualitative studies, and publication date1990-01-01 to 2023-10-23 (date of last search). All final searches were performed on October 23, 2023 by the librarian and were fully reported on October 25, 2023. The full search strategies as reported by the librarian are provided in Appendix(___). They are also archived at [DOI].
A summary of the search results from databases:
PubMed (NLM) from inception to 10/23/2023 (1,223 Results)
PsycInfo (EbscoHost) from inception to 6/2/2022 (1,225 Results)
CINAHL (EbscoHost) from inception to 6/2/2022 (502 Results)
Academic Search Complete (EbscoHost) from inception to 6/2/2022 (1,306 Results)
Web of Science (Clarivate Analytics) from inception to 6/2/2022 (728 Results)
The search resulted in 5,071 studies and 2,048 duplicate studies were found and omitted by the librarian using EndNote 20 and following the Wichor M. Bramer deduplication identification strategy available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915647/. This resulted in 3,017 records to screen from databases or registers and 6 records to screen from other methods, resulting in a total of 3,023 records. Studies were screened by title and abstract by two blinded and independent reviewers. If a tiebreaker was needed, a third reviewer was called in. This process was repeated for full text article screening and article selection.
Reference:
Schoonmade LJ. 2020. Qualitative Research Hedge. https://blocks.bmi-online.nl/catalog/293
To identify studies to include or consider for this meta-synthesis, the review team worked with a librarian (TN) to develop detailed search strategies for each database. The PRISMA-S extension was followed for search reporting. The librarian (TN) developed the search for [database] and translated the search for every database searched. The [database] search strategy was reviewed by the research team to check for accuracy and term relevancy. All final searches were peer-reviewed by another librarian (Jacob Brintzenhoff) following the Peer Review of Electronic Search Strategies (PRESS checklist). The search was limited by date from 1990-01-01 to 2023-10-23 (date of final search) The PubMed search used a Qualitative Research hedge, modified from Schoonade LJ. (1) and is available at https://blocks.bmi-online.nl/catalog/293.
2023-12-12T00:00:00Z