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The great escape: The power of cancer stem cells to evade programmed cell death
Castelli, V Giordano, A Benedetti, E Giansanti, F Quintiliani, M Cimini, A D’angelo, M
Castelli, V
Giordano, A
Benedetti, E
Giansanti, F
Quintiliani, M
Cimini, A
D’angelo, M
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Journal Article
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2021-01-02
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10.3390/cancers13020328
Abstract
© 2021 by the authors. Cancer is one of the primary causes of death worldwide. Tumour malignancy is related to tumor heterogeneity, which has been suggested to be due to a small subpopulation of tumor cells named cancer stem cells (CSCs). CSCs exert a key role in metastasis development, tumor recurrence, and also epithelial-mesenchymal transition, apoptotic resistance, self-renewal, tumorigenesis, differentiation, and drug resistance. Several current therapies fail to eradicate tumors due to the ability of CSCs to escape different programmed cell deaths. Thus, developing CSC-selective and programmed death-inducing therapeutic approaches appears to be of primary importance. In this review, we discuss the main programmed cell death occurring in cancer and the promising CSC-targeting agents developed in recent years. Even if the reported studies are encouraging, further investigations are necessary to establish a combination of agents able to eradicate CSCs or inhibit their growth and proliferation.
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