Thumbnail Image
Item

Glutathione in Brain Disorders and Aging

Iskusnykh, Igor Y.
; 
Zakharova, Anastasia A.
; 
Citations
Altmetric:
Genre
Journal article
Date
2022-01-05
Advisor
Committee member
Group
Department
Psychology and Neuroscience
Subject
Glutathione
 Brain
 Aging
 Disorders
 Neuron
Permanent link to this record
http://hdl.handle.net/20.500.12613/9276
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
PathakEtAl-JournalArticle-2022-01-A.pdf
Adobe PDF, 720.08 KB
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.3390/molecules27010324
Abstract
Glutathione is a remarkably functional molecule with diverse features, which include being an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in proteins, a stabilizer of cell membranes, and a detoxifier of xenobiotics. Glutathione exists in two states—oxidized and reduced. Under normal physiological conditions of cellular homeostasis, glutathione remains primarily in its reduced form. However, many metabolic pathways involve oxidization of glutathione, resulting in an imbalance in cellular homeostasis. Impairment of glutathione function in the brain is linked to loss of neurons during the aging process or as the result of neurological diseases such as Huntington’s disease, Parkinson’s disease, stroke, and Alzheimer’s disease. The exact mechanisms through which glutathione regulates brain metabolism are not well understood. In this review, we will highlight the common signaling cascades that regulate glutathione in neurons and glia, its functions as a neuronal regulator in homeostasis and metabolism, and finally a mechanistic recapitulation of glutathione signaling. Together, these will put glutathione’s role in normal aging and neurological disorders development into perspective.
Description
Citation
Iskusnykh, I.Y.; Zakharova, A.A.; Pathak, D. Glutathione in Brain Disorders and Aging. Molecules 2022, 27, 324. https://doi.org/10.3390/molecules27010324
Citation to related work
MDPI
Has part
Molecules, Vol. 27, Iss. 1
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos