Loading...
Development of a mobile phone camera-based transcutaneous bilirubinometer for low-resource settings
Harrison-Smith, Brandon Dumont, Alexander P. Lawal, Nuradeen Dobson, Dorianna Nwaba, Amy Grossarth, Sarah Paed, Abdulsalam Muhammed Farouk, Zubaida L.
Harrison-Smith, Brandon
Dumont, Alexander P.
Lawal, Nuradeen
Dobson, Dorianna
Nwaba, Amy
Grossarth, Sarah
Paed, Abdulsalam Muhammed
Farouk, Zubaida L.
Citations
Altmetric:
Genre
Journal article
Date
2022-04-15
Advisor
Committee member
Group
Department
Bioengineering
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.1364/boe.449625
Abstract
Newborns in high-income countries are routinely screened for neonatal jaundice using transcutaneous bilirubinometery (TcB). In low-and middle-income countries, TcB is not widely used due to a lack of availability; however, mobile-phone approaches for TcB could help expand screening opportunities. We developed a mobile phone-based approach for TcB and validated the method with a 37 patient multi-ethnic pilot study. We include a custom-designed snap-on adapter that is used to create a spatially resolved diffuse reflectance detection configuration with the illumination provided by the mobile-phone LED flash. Monte-Carlo models of reflectance from neonatal skin were used to guide the design of an adapter for filtered red-green-blue (RGB) mobile-phone camera reflectance measurements. We extracted measures of reflectance from multiple optimized spatial-offset regions-of-interest (ROIs) and a linear model was developed and cross-validated. This resulted in a correlation between total serum bilirubin and mobile-phone TcB estimated bilirubin with a R2= 0.42 and Bland-Altman limits of agreement of +6.4 mg/dL to -7.0 mg/dL. These results indicate that a mobile phone with a modified adapter can be utilized to measure neonatal bilirubin values, thus creating a novel tool for neonatal jaundice screening in low-resource settings.
Description
Citation
Brandon Harrison-Smith, Alexander P. Dumont, Mohammed Shahriar Arefin, Yu Sun, Nuradeen Lawal, Dorianna Dobson, Amy Nwaba, Sarah Grossarth, Abdulsalam Muhammed Paed, Zubaida L. Farouk, Jorn-Hendrik Weitkamp, and Chetan A. Patil, "Development of a mobile phone camera-based transcutaneous bilirubinometer for low-resource settings," Biomed. Opt. Express 13, 2797-2809 (2022)
Citation to related work
Optica Publishing Group
Has part
Biomedical Optics Express, Vol. 13, Iss. 5
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu