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Mitochondrial fission in hepatocytes as a potential therapeutic target for nonalcoholic steatohepatitis
Miyao, Masashi Kawai, Chihiro Kotani, Hirokazu Minami, Hirozo Abiru, Hitoshi Hamayasu, Hideki Eguchi, Satoru Tamaki, Keiji
Miyao, Masashi
Kawai, Chihiro
Kotani, Hirokazu
Minami, Hirozo
Abiru, Hitoshi
Hamayasu, Hideki
Eguchi, Satoru
Tamaki, Keiji
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Journal article
Date
2022-09-05
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Medicine
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DOI
http://dx.doi.org/10.1111/hepr.13832
Abstract
Aim: The mitochondria are highly plastic and dynamic organelles; mitochondrial dysfunction has been reported to play causative roles in diabetes, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). However, the relationship between mitochondrial fission and NAFLD pathogenesis remains unknown. We aimed to investigate whether alterations in mitochondrial fission could play a role in the progression of NAFLD. Methods: Mice were fed a standard diet or choline-deficient, L-amino acid-defined (CDAA) diet with vehicle or mitochondrial division inhibitor-1. Results: Substantial enhancement of mitochondrial fission in hepatocytes was triggered by 4 weeks of feeding and was associated with changes reflecting the early stage of human nonalcoholic steatohepatitis (NASH), steatotic change with liver inflammation, and hepatocyte ballooning. Excessive mitochondrial fission inhibition in hepatocytes and lipid metabolism dysregulation in adipose tissue attenuated liver inflammation and fibrogenesis but not steatosis and the systemic pathological changes in the early and chronic fibrotic NASH stages (4- and 12-week CDAA feeding). These beneficial changes due to the suppression of mitochondrial fission against the liver and systemic injuries were associated with decreased autophagic responses and endoplasmic reticulum stress in hepatocytes. Injuries to other liver cells, such as endothelial cells, Kupffer cells, and hepatic stellate cells, were also attenuated by the inhibition of mitochondrial fission in hepatocytes. Conclusions: Taken together, these findings suggest that excessive mitochondrial fission in hepatocytes could play a causative role in NAFLD progression by liver inflammation and fibrogenesis through altered cell cross-talk. This study provides a potential therapeutic target for NAFLD.
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Miyao M, Kawai C, Kotani H, Minami H, Abiru H, Hamayasu H, et al. Mitochondrial fission in hepatocytes as a potential therapeutic target for nonalcoholic steatohepatitis. Hepatol Res. 2022; 52(12): 1020–33. https://doi.org/10.1111/hepr.13832
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Hepatology Research, Vol. 52, Iss. 12
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