Loading...
Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
Still, Christopher D. Argyropoulos, George Edwards, Michael
Still, Christopher D.
Argyropoulos, George
Edwards, Michael
Citations
Altmetric:
Genre
Journal article
Date
2016-02-24
Advisor
Committee member
Group
Department
Surgery
Medical Genetics and Molecular Biochemistry
Medical Genetics and Molecular Biochemistry
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1155/2016/4390254
Abstract
Overweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood. The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D. Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects. BAs are involved in lipid and glucose homeostasis primarily via the farnesoid X receptor (FXR) transcription factor. BAs are also involved in regulating genes involved in inflammation, obesity, and lipid metabolism. Here, we review the novel role of BAs in bariatric surgery and the intersection between BAs and immune, obesity, weight loss, and lipid metabolism genes.
Description
Citation
Olivier F. Noel, Christopher D. Still, George Argyropoulos, Michael Edwards, Glenn S. Gerhard, "Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery", Journal of Obesity, vol. 2016, Article ID 4390254, 8 pages, 2016. https://doi.org/10.1155/2016/4390254
Citation to related work
Hindawi
Has part
Journal of Obesity, Vol. 2016
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu