Thumbnail Image
Item

Regulation of Id2 Gene Expression by the Insulin-like Growth Factor I Receptor Requires Signaling by Phosphatidylinositol 3-Kinase

Belletti, Barbara
; 
Prisco, Marco
; ; 
Valentinis, Barbara
; 
Navarro, Magali
; 
Baserga, Renato
Citations
Altmetric:
Genre
Journal article
Date
2001-04-27
Advisor
Committee member
Group
Department
Biology
Subject
Permanent link to this record
http://hdl.handle.net/20.500.12613/7104
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
Morrione-JournalArticle-2001-04-27.pdf
Adobe PDF, 579.94 KB
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1074/jbc.m010509200
Abstract
The Id proteins play an important role in proliferation, differentiation, and tumor development. We report here that Id gene expression can be regulated by the insulin-like growth factor I receptor (IGF-IR), a receptor that also participates in the regulation of cellular proliferation and differentiation. Specifically, we found that the IGF-IR activated by its ligand was a strong inducer of Id2 gene expression in 32D murine hemopoietic cells. This activation was not simply the result of cellular proliferation, as Id2 gene expression was higher in 32D cells stimulated by IGF-I than in cells exponentially growing in interleukin-3. The up-regulation of Id2 gene expression was largely dependent on the presence of insulin receptor substrate-1, a major substrate of the IGF-IR and a potent activator of the phosphatidylinositol 3-kinase (PI3K) pathway. The role of PI3K activity in the up-regulation of Id2 gene expression by the IGF-IR was confirmed by different methods and in different cell types. In 32D cells, the up-regulation of Id2 gene expression by the PI3K pathway correlated with interleukin-3 independence and inhibition of differentiation.
Description
Citation
Barbara Belletti, Marco Prisco, Andrea Morrione, Barbara Valentinis, Magali Navarro, Renato Baserga, Regulation of Id2 Gene Expression by the Insulin-like Growth Factor I Receptor Requires Signaling by Phosphatidylinositol 3-Kinase, Journal of Biological Chemistry, Volume 276, Issue 17, 2001, Pages 13867-13874, ISSN 0021-9258, https://doi.org/10.1074/jbc.M010509200.
Citation to related work
Elsevier
Has part
Journal of Biological Chemistry, Vol. 276, No. 17
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos