Loading...
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
Faria, Nuno R. Mellan, Thomas A. Whittaker, Charles Claro, Ingra M. Candido, Darlan da S. Mishra, Swapnil Crispim, Myuki A. E. Sales, Flavia C.S. Hawryluk, Iwona McGrone, John T.
Faria, Nuno R.
Mellan, Thomas A.
Whittaker, Charles
Claro, Ingra M.
Candido, Darlan da S.
Mishra, Swapnil
Crispim, Myuki A. E.
Sales, Flavia C.S.
Hawryluk, Iwona
McGrone, John T.
Citations
Altmetric:
Genre
Journal article
Date
2021-05-21
Advisor
Committee member
Group
Department
Biology
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1126/science.abh2644
Abstract
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.
Description
Citation
Citation to related work
American Association for the Advancement of Science
Has part
Science, Vol. 372
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu