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The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening
Galati, Alessandra Scatolini, Livia Micheli, Emanuela Bavasso, Francesca Cicconi, Alessandro Maccallini, Paolo Roake, Caitlin M. Schoeftner, Stefan Artandi, Steven E.
Galati, Alessandra
Scatolini, Livia
Micheli, Emanuela
Bavasso, Francesca
Cicconi, Alessandro
Maccallini, Paolo
Roake, Caitlin M.
Schoeftner, Stefan
Artandi, Steven E.
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Journal article
Date
2021-11-24
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Cancer and Cellular Biology
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https://doi.org/10.1002/1873-3468.14240
Abstract
Mutations in many genes that control the expression, the function, or the stability of telomerase cause telomere biology disorders (TBDs), such as dyskeratosis congenita, pulmonary fibrosis, and aplastic anemia. Mutations in a subset of the genes associated with TBDs cause reductions of the telomerase RNA moiety hTR, thus limiting telomerase activity. We have recently found that loss of the trimethylguanosine synthase TGS1 increases both hTR abundance and telomerase activity and leads to telomere elongation. Here, we show that treatment with the S-adenosylmethionine analog sinefungin inhibits TGS1 activity, increases the hTR levels, and promotes telomere lengthening in different cell types. Our results hold promise for restoring telomere length in stem and progenitor cells from TBD patients with reduced hTR levels.
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Citation
Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, et al. The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. FEBS Lett. 2021 Nov. 24;596: 42-52. doi:10.1002/1873-3468.14240.
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Wiley
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FEBS Letters, Vol. 596, Iss. 1
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