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Dishevelled and Wnt signaling: Is the nucleus the final frontier?

Habas, R
; 
Dawid, IB
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Genre
Journal Article
Date
2005-12-01
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Department
Subject
Adaptor Proteins, Signal Transducing
 Animals
 Cell Nucleus
 Dishevelled Proteins
 Humans
 Ligands
 Nuclear Envelope
 Phosphoproteins
 Protein Transport
 Signal Transduction
 Wnt Proteins
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http://hdl.handle.net/20.500.12613/5645
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Dishevelled and Wnt signaling is the nucleus the final frontier.pdf
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DOI
10.1186/jbiol22
Abstract
The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation. © 2005 BioMed Central Ltd.
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Springer Science and Business Media LLC
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Journal of Biology
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