Loading...
Is Hypertension Associated with Worse Renal Functional Outcomes after Minimally Invasive Partial Nephrectomy? Results from a Multi-Institutional Cohort
Flammia, Rocco Simone Anceschi, Umberto Tufano, Antonio Tuderti, Gabriele Ferriero, Maria Consiglia Brassetti, Aldo Mari, Andrea Di Maida, Fabrizio MInervii, Andrea Derweesh, Ithaar H.
Flammia, Rocco Simone
Anceschi, Umberto
Tufano, Antonio
Tuderti, Gabriele
Ferriero, Maria Consiglia
Brassetti, Aldo
Mari, Andrea
Di Maida, Fabrizio
MInervii, Andrea
Derweesh, Ithaar H.
Citations
Altmetric:
Genre
Journal article
Date
2022-02-25
Advisor
Committee member
Group
Department
Urology
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.3390/jcm11051243
Abstract
Background: Hypertension (HTN) is a global public health issue. There are limited data regarding the effects of HTN in patients undergoing partial nephrectomy (PN) for renal tumors. To address this void, we tested the association between HTN and renal function after minimally invasive PN (MIPN). Methods: Using a multi-institutional database (2007–2017), we identified patients aged ≥ 18 years with a diagnosis of cT1 renal tumors treated with MIPN. Kaplan–Meier plots and Cox regression models addressed newly-onset CKD stage ≥ 3b or higher (sCKD). All analyses were repeated after 1:1 propensity score matching (PSM). Results: Overall, 2144 patients were identified. Of those, 35% (n = 759) were yes-HTN. Yes-HTN patients were older, more frequently male and more often presented with diabetes. Yes-HTN patients harbored higher RENAL nephrometry scores and higher cT stages than no-HTN patients. Conversely, yes-HTN patients exhibited lower preoperative eGFRs. In the overall cohort, five-year sCKD-free survival was 86% vs. 94% for yes-HTN vs. no-HTN, which translated into a multivariable HR of 1.67 (95% CI: 1.06–2.63, p = 0.026). After 1:1 PSM, virtually the same results were observed (HR 1.86, 95% CI: 1.07–3.23, p = 0.027). Conclusions: Yes-HTN patients exhibited worse renal function after MIPN when compared to their no-HTN counterparts. However, these observations need to be further tested in a prospective cohort study.
Description
Citation
Flammia, R.S.; Anceschi, U.; Tufano, A.; Tuderti, G.; Ferriero, M.C.; Brassetti, A.; Mari, A.; Di Maida, F.; Minervini, A.; Derweesh, I.H.; et al. Is Hypertension Associated with Worse Renal Functional Outcomes after Minimally Invasive Partial Nephrectomy? Results from a Multi-Institutional Cohort. J. Clin. Med. 2022, 11, 1243. https://doi.org/10.3390/jcm11051243
Citation to related work
MDPI
Has part
Journal of Clinical Medicine, Vol. 11, Iss. 5
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu